Boc-D-Val-OH

eptide conformation, receptor binding, and metabolic stability. The Boc protecting group in Boc-D-Val-OH is essential for preventing undesired side reactions during peptide assembly, ensuring that chain elongation proceeds with high fidelity and yield. Beyond peptide synthesis, Boc-D-Val-OH serves as a versatile intermediate in the preparation of D-valine-containing pharmaceuticals, enzyme inhibitors, and biologically active compounds, with documented applications in the synthesis of selective CCR1 antagonists for rheumatoid arthritis and antileishmanial agents. The branched isopropyl side chain of Boc-D-Val-OH also contributes to the hydrophobic character of peptides containing this residue, influencing membrane permeability and bioavailability of the final therapeutic product.

 

 Product Parameters

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Parameter	Specification
Product Name	Boc-D-Val-OH
CAS Number	22838-58-0
Molecular Formula	C₁₀H₁₉NO₄
Molecular Weight	217.26 g/mol
Appearance	White solid
Melting Point	164–165 °C (decomp.)
Boiling Point	357.82 °C (rough estimate)
Density	1.1518 (rough estimate)
pKa	4.01 ± 0.10 (predicted)
Solubility	Soluble in DMSO and methanol
Storage Condition	Keep in dark place, sealed in dry, room temperature

 

Application

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Boc-D-Val-OH  can be used to prepare selective CCR1 antagonists for the treatment of rheumatoid arthritis, as well as formulations against Leishmania. It is an amino-protected derivative of D-valine and a common pharmaceutical chemical intermediate.

 

Synthetic Route

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Add D-valine, 20 mL of ethyl acetate, and 10 mL of tetrahydrofuran to the reaction flask. Add 4.2 g (19.3 mmol) of Boc anhydride to the reaction mixture and stir at room temperature for 6 hours. Monitor the reaction progress by thin-layer chromatography until completion. Centrifugally evaporate the reaction mixture to dryness, add saturated ammonium chloride solution to the residue, separate the organic phase, wash with saturated saline solution, dry, filter under vacuum, and centrifugally evaporate to dryness to obtain Boc-D-Val-OH.

 

Product Quality Assurance

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Cosperpharm has established a comprehensive quality assurance system for Boc-D-Val-OH that meets the rigorous expectations of both peptide synthesis intermediate manufacturing and reference standard applications:

 

Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: HPLC purity (≥98.0% industrial grade; ≥95.0% reference standard grade, with full chromatographic traceability), optical rotation verification ([α]²⁰/D +5.0 to +8.0°, c=1 in acetic acid), melting point verification (76.0–80.0 °C), appearance verification (white to almost white powder to crystal), water content determination (Karl Fischer <0.5%), residual solvent analysis (GC), and where applicable, ¹H NMR and MS confirmation of molecular identity.

 

Full batch traceability with retention samples. From raw material procurement (D-valine from qualified suppliers) through Boc protection, purification, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with sufficient retention samples maintained in accordance with Cosperpharm quality procedures.

 

Stability monitoring program. Cosperpharm conducts ongoing stability studies under recommended storage conditions: long-term storage at –20 °C under inert atmosphere, with accelerated stability studies (40 °C / 75% RH) conducted on representative batches. Stability summaries are updated regularly, with full data packages available to support customer regulatory submissions. Shelf life: 3 years at –20 °C; 2 years at 4 °C.

 

Documentation ready for regulatory submission. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, a Material Safety Data Sheet (SDS), and customs documentation for international delivery. For customers preparing regulatory filings for peptide-based therapeutics, Cosperpharm provides DMF-ready documentation packages, method validation reports, stability data, and custom quality agreements upon request.

 

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm's manufacturing, quality control, and documentation facilities. Please contact our regulatory team to schedule an audit. ISO compliance documentation is available upon request.

 

Contact Us

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Cosperpharm is your trusted partner for Boc-protected D-amino acids and peptide synthesis intermediates. Whether you're developing the next generation of D-peptide therapeutics or scaling up a commercial manufacturing process, our team is ready to support you with high-quality Boc-D-Val-OH and responsive technical service. Contact us today to discuss your requirements.