Boc-Gly-OH

Boc-Gly-OH is a fundamental amino acid building block widely employed in peptide synthesis, serving as a protecting group for glycine during the synthesis of peptides and allowing for selective reactions without affecting other functional groups. Boc-Gly-OH is the standard building block for the introduction of glycine amino-acid residues by Boc solid-phase peptide synthesis (Boc SPPS). Boc-Gly-OH can be used for the esterification reaction to synthesize N-Boc amino acid esters for peptide chemistry, as well as for the synthesis of tripeptide H-Gly-Pro-Glu-OH, an analog of neuroprotective drugs. Additionally, Boc-Gly-OH serves as a promoter for the allylation of hydrazones and isatin, demonstrating its versatility beyond standard peptide synthesis. In pharmaceutical research, Boc-Gly-OH contributes to the development of drug candidates by enhancing their stability and bioavailability.

Product Parameters

Application

Synthetic Route

Extract impurities three times using 12 mL of n-hexane per extraction cycle according to Chemicalbook. After adjusting the pH to 3 with 3 mol/L hydrochloric acid, extract the product three times using 0.6 L of dioxane per cycle. Combine the ester layers and wash with saline solution until neutrality is achieved. Add 15 g of anhydrous sodium sulfate and dry for 10 hours.

The filtrate was filtered, then concentrated under reduced pressure and dried. Subsequently, 60 mL of n-hexane was added and stirring was performed to induce crystallization. The product was obtained by centrifugation and dried, yielding 25.0 g of product with a yield of 93.87%.

Product Quality Assurance

Cosperpharm has established a comprehensive quality assurance system for Boc-Gly-OH that meets the rigorous expectations of peptide synthesis and pharmaceutical research applications:

Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: HPLC purity (≥98%), titration purity (≥99.0%), melting point verification (87.0–90.0 °C), appearance verification (white to off-white crystalline powder), and ignition residue testing (≤0.05%).

Full batch traceability. From raw material procurement through protection, purification, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with retention samples maintained in accordance with Cosperpharm quality procedures.

Stability monitoring program. Cosperpharm conducts ongoing stability studies under recommended storage conditions (cool, dry place; 0–10 °C). Stability summaries are available to support customer regulatory submissions.

Documentation ready for regulatory submission. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, a Safety Data Sheet (SDS), and customs documentation. For customers developing peptide-based therapeutics, Cosperpharm provides comprehensive documentation packages upon request.

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm's manufacturing, quality control, and documentation facilities. Please contact our regulatory team to schedule an audit.

Contact Us

Whether you need Boc-Gly-OH for routine peptide synthesis, drug development research, or commercial manufacturing, Cosperpharm is your trusted partner. Contact us today to discuss your requirements, request a quote, or learn more about our documentation and quality assurance programs.