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Product Name |
CAS No. |
|
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DMT-2'-OMe-A(Bz)-CE-Phosphoramidite |
110782-31-5 |
|
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DMT-2'-OMe-G(iBu)-CE-Phosphoramidite |
150780-67-9 |
|
|
DMT-2'-OMe-C(Ac)-CE-Phosphoramidite |
199593-09-4 |
|
|
DMT-2'-OMe-U-CE-Phosphoramidite |
110764-79-9 |
|
2'-O-Methyl phosphoramidites are indispensable building blocks for synthesizing oligonucleotides that require enhanced metabolic stability and higher binding affinity to target RNA or DNA. By introducing a methyl group at the 2' position of the ribose sugar, this modification significantly increases resistance to nuclease degradation while maintaining the ability to form stable duplexes. These properties make 2'-OMe phosphoramidites a preferred choice for therapeutic applications, including antisense therapeutics, siRNA, and CRISPR guide RNAs, where precision and durability are paramount.
To ensure optimal performance and prolong the shelf life of our 2'-O-Methyl phosphoramidites, strict storage protocols must be followed. These products should be stored desiccated at -20°C, protected from light and moisture. Under these recommended conditions, the compounds remain stable for up to 12 months. For short-term handling, ensure vials are allowed to equilibrate to room temperature before opening to prevent condensation. Once dissolved in anhydrous acetonitrile, solutions should be used promptly or stored under inert gas to maintain integrity.
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