DMT-dT-CE-Phosphoramidite is the standard, high-purity DNA monomer for introducing thymidine into synthetic oligonucleotide chains. As a fundamental building block, DMT-dT-CE-Phosphoramidite is rigorously tested for high coupling efficiency, ensuring the synthesis of high-fidelity DNA sequences for a vast range of applications. The robust protecting group scheme of DMT-dT-CE-Phosphoramidite is compatible with standard DNA synthesis platforms, making DMT-dT-CE-Phosphoramidite the most widely used and reliable monomer for de novo DNA engineering.
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Parameter |
Specification |
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Product Name |
DMT-dT-CE-Phosphoramidite |
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CAS Number |
98796-51-1 |
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Molecular Formula |
C₄₀H₄₉N₄O₈P |
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Molecular Weight |
744.81 g/mol |
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Purity (HPLC) |
≥98.0% |
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Physical Form |
Solid powder |
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Appearance |
White to off-white powder |
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Storage Condition |
Sealed in dry,2-8°C |
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kPa |
9.55±0.10(Predicted) |
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Density |
1.22 at20℃ |
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Advantage |
Detail |
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Production Strength |
GMP-certified campus spanning 100+ mu, 3 multi-purpose workshops, 6 D-grade clean zone production lines, and 150+ reactors (20L–5000L), supporting high/low temp, anaerobic & hydrogenation; kg to ton scale production. |
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Fast Delivery |
R&D samples: one week; commercial orders: 1–2 months after payment. Express (DHL/FedEx) or air/sea freight available. |
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Global Partners |
Trusted by 30+ pharmaceutical companies in USA, Europe, India, Brazil, and Southeast Asia; long-term cooperation with generic drug manufacturers, CROs, and impurity standard distributors. |
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Licensed Exporter |
Valid drug import/export license — no compliance delays. |
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Dual Quality Grades |
Both research/pharma grade（≥98%）and high-purity impurity grade（≥99%）available to meet diverse customer needs. |
Using bis(2-isopropylamino)(2-cyanethyl)phosphine and protected thymidine as starting materials, the general procedure for synthesizing (2R,3S,5R)-2-(bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl(2-chloroethyl)disoisopropyl phosphinamide is as follows: Three distinct phosphination reactions were carried out in the presence of a pyridine-TFA activator, wherein the protected nucleoside reagent was reacted with 2-cyanethyl-N,N,N ',N' -tetraisopropyl phosphinamide, and the yields of each reaction were calculated.
Q1: What is the difference between DMT-dT-CE-Phosphoramidite and other DNA amidites?
A: DMT-dT-CE-Phosphoramidite is the specific monomer for the nucleobase thymine (T). Other amidites (for A, C, G) have different protecting groups on their exocyclic amines. DMT-dT-CE-Phosphoramidite does not require additional base protection, simplifying its synthesis and deprotection.
Q2: Why is the DMT group used?
A: The dimethoxytrityl (DMT) group protects the 5'-hydroxyl. It is acid-labile, allowing for selective removal (detritylation) at each synthesis cycle to extend the oligonucleotide chain. Its purple-orange color also allows for easy monitoring of synthesis efficiency.
Optimizing your oligonucleotide manufacturing? Let Cosperpharm supply consistent DMT-dT-CE-Phosphoramidite with full batch traceability. Reach our team to discuss volume discounts and custom packaging.
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No. 2 Yangguang 3rd Road, Duodao Chemical Cycle Industrial Park, Jingmen City, Hubei Province, China
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