Fmoc-beta-Ala-OH

Fmoc-beta-Ala-OH is a standard building block for introducing β-alanine residues into peptide sequences via Fmoc solid-phase peptide synthesis. Fmoc-beta-Ala-OH features the Fmoc protecting group that enhances stability during solid-phase peptide construction, allowing chemists to introduce β-alanine residues without premature detachment. Fmoc-beta-Ala-OH has been used in the solid-phase synthesis of glucagon receptor peptide antagonists and bradykinin B1 and B2 receptor pseudopeptide antagonists. Fmoc-beta-Ala-OH is supplied as a white to light yellow crystalline powder with a melting point of 142–147 °C and is soluble in water and 1% acetic acid.

Product Parameters

FAQ

Q1: What is Fmoc-beta-Ala-OH?

A: Fmoc-beta-Ala-OH (CAS 35737-10-1) is an Fmoc-protected β-amino acid (3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)propanoic acid) used as a building block in peptide synthesis.

Q2: How does Fmoc-beta-Ala-OH differ from Fmoc-Ala-OH?

A: Fmoc-beta-Ala-OH is a β-amino acid with the amino group at the β-position (carbon 3), resulting in a three-carbon backbone (H₂N-CH₂-CH₂-COOH). Fmoc-Ala-OH is an α-amino acid with a two-carbon backbone. This structural difference provides unique conformational properties when incorporated into peptides.

Storage Conditions

Store Fmoc-beta-Ala-OH in a tightly sealed container at 2–8 °C. Keep the container cool and dry, stored in a clean, well-ventilated area away from strong oxidizing agents and strong bases. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Shelf life: 2–3 years when stored at 2–8 °C in a sealed container under recommended conditions.

Handling precautions: Do not breathe dust. Avoid contact with skin and eyes. Use standard laboratory practices for handling fine chemicals. Wear appropriate personal protective equipment including lab coat, safety goggles, and chemical-resistant gloves. Avoid generating dust. Wash hands thoroughly after handling.

Application Scenarios

Fmoc Solid-Phase Peptide Synthesis (SPPS)

Fmoc-beta-Ala-OH is a standard building block for introducing β-alanine residues via Fmoc SPPS. The Fmoc group enhances stability during solid-phase peptide construction.

Glucagon Receptor Peptide Antagonist Synthesis

Fmoc-beta-Ala-OH has been used in the solid-phase synthesis of glucagon receptor peptide antagonists.

Bradykinin Receptor Pseudopeptide Antagonist Synthesis

Used in the synthesis of bradykinin B1 and B2 receptor pseudopeptide antagonists.

Peptide Linker Synthesis

Fmoc-beta-Ala-OH is used as a linker to synthesize peptides on various solid-phase matrix systems via Fmoc SPPS.

Analytical Method Development & Validation

Fmoc-beta-Ala-OH can be used for analytical method development, method validation (AMV), and quality control (QC) applications for Abbreviated New Drug Applications (ANDA).

Pharmaceutical Peptide Manufacturing

Used in the commercial production of peptide-based therapeutics and pseudopeptide drugs.

Medicinal Chemistry & Drug Discovery

Researchers use Fmoc-beta-Ala-OH in the synthesis of peptide libraries, lead compounds, and structure-activity relationship (SAR) studies.

Organic Synthesis

Fmoc-beta-Ala-OH is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals, and dyestuffs.

Process Development & Scale-Up

Pharmaceutical process chemists use this intermediate for developing scalable manufacturing routes for peptide-based therapeutics.

Contact Us

Looking for Fmoc-beta-Ala-OH for your peptide synthesis or drug discovery program? Cosperpharm offers the quality, consistency, and supply reliability that researchers and manufacturers depend on. Whether you need a few grams for medicinal chemistry or larger quantities for commercial production, we deliver with transparent lead times and full documentation. Reach out to our team today—we are ready to support your next project.