Fmoc-D-Trp-OH

Fmoc-D-Trp-OH is a high-purity Fmoc-protected amino acid derivative widely employed as a standard building block in Fmoc solid-phase peptide synthesis for the introduction of D-tryptophan residues. As a D-configured tryptophan derivative, Fmoc-D-Trp-OH enables researchers to access D-amino acid-containing peptides with enhanced resistance to proteolytic degradation and distinct biological activities compared to their L-counterparts. Fmoc-D-Trp-OH is characterized by its white to light yellow to light orange crystalline powder appearance, with a melting point of 182–186 °C and a specific optical rotation of +26.0 to +31.0° (c=1, DMF). In peptide synthesis applications, Fmoc-D-Trp-OH serves as the preferred reagent for incorporating D-tryptophan at defined positions within peptide sequences, supporting structure-activity relationship studies, receptor-binding investigations, and the development of metabolically stable peptide therapeutics. Fmoc-D-Trp-OH is supplied with rigorous analytical characterization including HPLC purity verification, ensuring reliable and reproducible results in both research and process development settings.

Product Parameters

Cosperpharm has established a comprehensive quality assurance system for Fmoc-D-Trp-OH that meets the rigorous expectations of peptide synthesis and pharmaceutical research applications:
 
Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: HPLC purity (≥97.0% with full chromatographic traceability), optical rotation verification ([α]²⁰/D +26.0 to +31.0°), melting point confirmation (182–186 °C), appearance verification (white to light yellow to light orange powder to crystal), and where applicable, ¹H NMR and mass spectrometry confirmation of molecular identity.
 
Full batch traceability with retention samples. From raw material procurement through Fmoc protection, purification, crystallization, drying, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with sufficient retention samples maintained in accordance with Cosperpharm quality procedures.
 
Stability monitoring program. Cosperpharm conducts ongoing stability studies under recommended storage conditions, with data available to support customer research and development programs. Shelf life: 3 years at –20 °C; 2 years at 4 °C.
 
Documentation ready for research and regulatory use. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, and customs documentation for international delivery. For customers developing peptide-based therapeutics, Cosperpharm provides additional documentation upon request, including stability summaries and custom quality agreements.
 
Storage Conditions

Sourcing Fmoc-D-Trp-OH for your peptide synthesis program, structure-activity relationship study, or drug discovery campaign should be straightforward. Cosperpharm makes it simple — reach out to our team today for pricing, availability, or technical support.