H-N-Me-Trp(Boc)-OAll Oxalate

H-N-Me-Trp(Boc)-OAll Oxalate is a sophisticated building block for the synthesis of N-methylated tryptophan-containing peptides and peptidomimetics. The orthogonal protection strategy of H-N-Me-Trp(Boc)-OAll Oxalate — with Boc on the indole nitrogen, allyl ester at the C-terminus, and a free Nα-methyl amino group — allows for flexible peptide elongation and selective deprotection. H-N-Me-Trp(Boc)-OAll Oxalate is particularly valuable for the synthesis of cyclic peptides, backbone-modified peptides, and N-methylated analogues that exhibit enhanced metabolic stability and improved pharmacokinetic properties. The presence of the N-methyl group in H-N-Me-Trp(Boc)-OAll Oxalate reduces the peptide backbone's hydrogen-bonding capacity, which can improve membrane permeability and oral bioavailability — a strategy widely employed in peptide drug discovery. H-N-Me-Trp(Boc)-OAll Oxalate is typically supplied at ≥98% purity and is intended for research use only.

Product Parameters

Why Cosperpharm?

When your peptide drug discovery program requires specialized N-methylated amino acid building blocks, Cosperpharm delivers H-N-Me-Trp(Boc)-OAll Oxalate with the purity and documentation that medicinal chemistry research demands.

Specialized building blocks for advanced peptide chemistry. N-methylated amino acids are essential tools for improving peptide drug properties — enhancing metabolic stability, increasing membrane permeability, and modulating target selectivity. H-N-Me-Trp(Boc)-OAll Oxalate provides the N-methyl tryptophan motif with orthogonal protection for flexible synthetic strategies.

Purity that ensures research reproducibility. At ≥98% purity, H-N-Me-Trp(Boc)-OAll Oxalate delivers the consistency required for reliable peptide synthesis and structure-activity relationship studies. Every batch is characterized to ensure your research proceeds without confounding impurities.

Documentation that supports your research. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity data. Custom documentation packages are available upon request for research programs requiring detailed characterization.

Flexible supply for research programs. Cosperpharm supplies H-N-Me-Trp(Boc)-OAll Oxalate in research quantities (1g, 5g, and custom sizes) to support peptide library synthesis, hit-to-lead optimization, and preclinical development programs. R&D samples ship within 5–7 business days.

Technical support for peptide chemists. Our team can advise on deprotection strategies, coupling conditions, and compatibility with various peptide synthesis platforms — because we understand the challenges of working with N-methylated amino acids.

Product Advantages

 N-Methylated Tryptophan for Peptide Drug Discovery

The N-methyl group in H-N-Me-Trp(Boc)-OAll Oxalate reduces backbone hydrogen bonding, which can improve membrane permeability and oral bioavailability — critical properties for peptide drug development. This modification also enhances metabolic stability by blocking cleavage by certain proteases.

 Orthogonal Protection for Flexible Synthesis

H-N-Me-Trp(Boc)-OAll Oxalate features three orthogonal protecting groups: Boc on the indole nitrogen (acid-labile), allyl ester at the C-terminus (Pd-labile), and the free Nα-methyl amino group for peptide elongation. This allows for selective deprotection and flexib

le peptide assembly strategies.

 Tryptophan Side Chain Pharmacophore

The indole side chain of H-N-Me-Trp(Boc)-OAll Oxalate provides the characteristic tryptophan pharmacophore, which is essential for receptor binding in numerous bioactive peptides targeting serotonin, neurotensin, and other receptors.

 Oxalate Salt for Improved Handling

The oxalate salt form of H-N-Me-Trp(Boc)-OAll Oxalate enhances crystallinity and handling properties compared to the free base, facilitating accurate weighing and storage.

Product Quality Assurance

Cosperpharm has established a quality assurance system for H-N-Me-Trp(Boc)-OAll Oxalate that meets the expectations of peptide drug discovery and medicinal chemistry research:

Analytical characterization. Each batch undergoes HPLC purity verification (≥98%) and identity confirmation. Additional characterization data (NMR, MS) are available upon request.

Full batch traceability. From raw material procurement through synthesis, purification, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with retention samples maintained in accordance with Cosperpharm quality procedures.

Documentation for research programs. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity data. Custom documentation packages are available upon request for research programs requiring detailed characterization.

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm's manufacturing and quality control facilities. Please contact our team to schedule an audit.

Contact Us

Advancing your peptide drug discovery program requires access to high-quality specialized building blocks. Cosperpharm provides H-N-Me-Trp(Boc)-OAll Oxalate with the purity and support your research demands. Get in touch with our team to discuss your requirements or place an order.