Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester

Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester is an amino alcohol ester building block that has been primarily investigated as a synthetic intermediate in the construction of ionizable lipid libraries for lipid nanoparticle (LNP)-mediated nucleic acid delivery. The secondary amine in Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester serves as the critical ionizable center, designed to remain uncharged at physiological pH (7.4) while becoming protonated in the acidic endosomal environment (pH 5.0–6.5), thereby facilitating endosomal escape through the proton sponge effect and subsequent cytosolic delivery of mRNA or siRNA payloads. The branched 1-hexylnonyl ester tail in Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester imparts a characteristic conical molecular geometry that favors the formation of inverted hexagonal (HII) phase structures, a biophysical property that has been correlated with efficient membrane fusion and nucleic acid release. The terminal 4-hydroxybutyl group provides a synthetic handle for further derivatization. Structurally related amino alcohol lipidoids are pivotal in creating nucleic acid delivery systems and form a crucial component of nanolipid particles used for delivery vectors. The availability of Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester as a high-purity intermediate supports the rational design and systematic optimization of next-generation ionizable lipids for mRNA vaccines, gene editing (CRISPR-Cas9) therapeutics, and RNA interference-based treatments.

Product Parameters

Why Cosperpharm?

When your ionizable lipid synthesis or LNP formulation program requires a high-purity, reliably sourced amino alcohol ester building block, Cosperpharm delivers Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester with the documentation depth, supply consistency, and technical guidance that medicinal chemists and formulation scientists demand.

Certified purity for reproducible lipid synthesis. Each batch of Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester undergoes rigorous HPLC purity verification to ensure consistent quality. Given the presence of the secondary amine—which can undergo oxidation or premature alkylation—and the ester linkage—which is susceptible to hydrolysis—careful analytical characterization is essential to confirm the integrity of all functional groups prior to use in multi-step lipidoid synthesis.

Documentation structured for your research records. Every shipment of Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester includes a comprehensive Certificate of Analysis (COA) with batch-specific HPLC purity data and analytical traces. Our documentation is formatted for direct incorporation into your laboratory notebooks, publications, or patent filings, with DMF-ready quality statements available upon request.

Scalable supply with transparent timelines. Cosperpharm provides Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester in quantities ranging from milligram amounts for initial screening and reaction optimization to multi-gram batches for scaled-up lipid library synthesis and formulation development. Lead times are confirmed at the point of inquiry, enabling you to align procurement with research milestones.

Technical guidance on handling and lipid chemistry. Our application scientists possess deep knowledge of amino alcohol ester chemistry and the handling of ionizable lipid intermediates. They can provide practical guidance on storage, acylation conditions, and compatibility of Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester with common synthetic transformations, including esterification of the terminal hydroxyl group and subsequent derivatization of the secondary amine.

Global logistics with complete documentation. Cosperpharm ships Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester to academic laboratories, pharmaceutical companies, and CROs worldwide, with all customs paperwork provided. Appropriate temperature-controlled packaging is used to maintain product integrity during transit.

FAQ

Q1: How should Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester be stored?

A: For long-term integrity, store at –20 °C in a tightly sealed container under an inert atmosphere of nitrogen or argon, protected from light and moisture. The secondary amine is susceptible to oxidation, and the ester linkage may undergo slow hydrolysis under humid conditions. Allow the sealed container to equilibrate to ambient temperature before opening.

Q2: What are the primary research applications of this compound?

A: Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester is primarily used as a synthetic intermediate in the construction of ionizable lipid libraries for LNP-mediated mRNA and siRNA delivery. The secondary amine provides pH-responsive endosomal escape functionality, and the branched ester tail promotes fusogenic molecular geometry. Structurally related lipid compounds are pivotal in creating nucleic acid delivery systems and form crucial components of nanolipid particles used for delivery vectors .

Application Scenarios

Ionizable Lipid Synthesis for mRNA Delivery

Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester serves as a key synthetic intermediate in the construction of ionizable lipids for mRNA-LNP formulations, including vaccine and therapeutic applications. The secondary amine provides the pH-responsive ionizable center critical for endosomal escape.

Lipidoid Library Combinatorial Synthesis

Employed as a versatile building block in the combinatorial construction of structurally diverse lipidoid libraries, where the secondary amine can be derivatized with various electrophiles to generate libraries for systematic structure–activity relationship studies.

siRNA and Gene Silencing Delivery Systems

Used in the synthesis of ionizable lipids formulated into LNPs for siRNA delivery, where efficient endosomal escape mediated by the protonatable amine is essential for achieving potent gene knockdown.

CRISPR-Cas9 Ribonucleoprotein Delivery

Serves as a precursor in the development of biodegradable ionizable lipids for the co-delivery of Cas9 mRNA and single guide RNA (sgRNA) or for direct ribonucleoprotein delivery in gene editing applications.

Structure–Activity Relationship (SAR) Optimization

The well-defined structure and multiple sites for derivatization make Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester a versatile platform for systematically varying the ester tail length, branching, and head group composition to optimize delivery efficiency and tissue tropism.

Endosomal Escape Mechanism Studies

Used as a model ionizable lipid component in biophysical investigations of pH-dependent membrane fusion, lipid phase transitions (lamellar to HII), and the molecular determinants of endosomal escape efficiency.

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Ready to evaluate Heptanoic acid, 7-[(4-hydroxybutyl)amino]-, 1-hexylnonyl ester for your ionizable lipid research program? We’ll put together a tailored quote as soon as we hear from you.