N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alaninel-Methylethyl ester

N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alaninel-Methylethyl ester – Precise Targeting, Unlocking Value: As a core building block of Sofosbuvir (GS-7977), N-[(S)-(2,3,4,5,6-pentafluorophenoxy) phenoxyphosphinyl]-L-alanine 1-methylethyl ester is primarily used to introduce the key phosphoryl side chain. Its optical and chemical purity directly determine the quality and efficacy of the final Sofosbuvir API, making it a critical link in the R&D and quality control of hepatitis C treatments.

Beyond Impurity, Delivering Value: N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alaninel-Methylethyl ester is not a useless by‑product. As an impurity standard, our product, backed by detailed characterization data compliant with pharmacopoeial standards, serves as a "ruler" in analytical method validation (AMV) and quality control (QC). Simultaneously, it is an active intermediate for synthesizing phosphoramidate prodrugs with higher anti‑HCV activity. This dual role makes N-[(S)-(2,3,4,5,6-pentafluorophenoxy) phenoxyphosphinyl]-L-alaninel-Methylethyl ester indispensable at different stages of drug R&D.

Process Innovation, Cost Advantage: Leveraging our GMP-certified manufacturing base and multiple flexible production lines, we achieve seamless scale-up from R&D to commercial cGMP production. Our synthetic process employs innovative chiral induction technology to ensure high batch-to-batch consistency. A stable supply chain shortens lead times to 1–2 weeks and offers competitive pricing for long-term partners.

Product Parameters

Product Features & Quality Commitment

● Fast Delivery: Standard specifications are in stock, ready to ship within 1 week after order confirmation.

● High Purity: Produced with state-of-the-art purification processes to meet or exceed customer purity requirements.

● Customizable Packaging: Available in various pack sizes from grams to kilograms; special packaging available on request.

● Technical Support: Our expert technical team is available to assist with process development and regulatory filing inquiries.

Frequently Asked Questions (FAQ)

Q1: Is this intermediate primarily used for generic (ANDA) or innovative drug R&D?

A: Both. It is a critical tool for impurity profiling and quality research in Sofosbuvir generic development, as well as a core raw material for originator companies and CRO/CDMOs exploring new synthetic routes or novel molecules in process R&D.

Q2: Does the product require special temperature control during shipping?

A: Under normal transport conditions, the compound is stable and can be shipped as a regular chemical without a cold chain. All orders are sealed in high-barrier packaging with shock-absorbing material.

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