|
Product Name |
CAS No. |
. |
|
2'-F-dU-ANA-CE-Phosphoramidite |
1190089-70-3 |
|
|
2'-F-dC(Ac)-ANA-CE-Phosphoramidite |
N/A |
|
|
2'-F-dA(Bz)-ANA-CE-Phosphoramidite |
329187-86-2 |
|
|
2'-F-dG(iBu)-ANA-CE-Phosphoramidite |
1404463-20-2 |
|
Unique Conformational Locking: The 2'-FANA modification forces the sugar into a C2'-endo conformation, which is different from the C3'-endo conformation typical of RNA or the standard DNA duplex. This unique structural feature allows FANA-modified oligonucleotides to form highly stable duplexes with both RNA and DNA targets, offering exceptional binding affinity and sequence specificity.
Enhanced Enzymatic Resistance: The presence of the fluorine atom at the 2' position, combined with the arabinose geometry, creates a powerful steric and electronic shield against nucleases. This translates to significantly extended half-lives in vivo, making FANA an excellent choice for therapeutic development.
Superior Specificity and Potency: FANA-modified oligomers have been shown to reduce off-target effects and immune stimulation compared to some other modifications. The unique conformation enhances the formation of the RNA-induced silencing complex (RISC) in siRNA applications and improves the potency of antisense therapeutics.
High Purity and Reliable Coupling: Every lot of Cosperpharma’s FANA phosphoramidites is produced under strict anhydrous conditions and undergoes rigorous HPLC purity analysis to ensure the highest coupling efficiency and product fidelity for your most sensitive applications.
2'-FANA (2'-Deoxy-2'-fluoro-arabinonucleic acid) is a structural analog of RNA where the ribose sugar is replaced by an arabinose sugar, and the 2'-hydroxyl group is substituted with a highly electronegative fluorine atom. This unique combination provides remarkable stability and binding properties that are distinct from both standard RNA and other 2'-modifications like 2'-OMe or 2'-F-RNA. Cosperpharma’s 2'-FANA Phosphoramidites are designed for seamless incorporation into standard solid-phase synthesis protocols, allowing researchers to easily explore the benefits of this innovative chemistry in their next-generation therapeutic designs.
We are eager to collaborate with you on your next breakthrough in nucleic acid therapeutics. If you are interested in exploring the unique properties of our 2'-FANA Phosphoramidites for your project, our expert team is ready to assist. Contact Cosperpharma today to request a sample, discuss custom synthesis requirements, or receive a detailed specification sheet.
