tert-Butyl ((1S)-3-{2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl}-1-[(5,5-difluoro-2-oxopiperidin-1-yl)methyl]-3-oxopropyl)carbamate

tert‑Butyl ((1S)‑3‑{2,4‑bis(trifluoromethyl)‑5,8‑dihydropyrido[3,4‑d]pyrimidin‑7(6H)‑yl}‑1‑[(5,5‑difluoro‑2‑oxopiperidin‑1‑yl)methyl]‑3‑oxopropyl)carbamate is a critical intermediate in the industrial synthesis of gemigliptin, a DPP‑4 inhibitor indicated for type 2 diabetes. Gemigliptin can be used as monotherapy or in combination with other antidiabetic agents such as metformin. The pyridopyrimidine core of tert‑Butyl ((1S)‑3‑{2,4‑bis(trifluoromethyl)‑5,8‑dihydropyrido[3,4‑d]pyrimidin‑7(6H)‑yl}‑1‑[(5,5‑difluoro‑2‑oxopiperidin‑1‑yl)methyl]‑3‑oxopropyl)carbamate provides the essential heterocyclic framework for DPP‑4 inhibitory activity. The compound is also known as Gemigliptin tert‑butyl carbamate and is used as an analytical standard for HPLC as well as in R&D of DPP‑4 inhibitor drugs. In quality control contexts, tert‑Butyl ((1S)‑3‑{2,4‑bis(trifluoromethyl)‑5,8‑dihydropyrido[3,4‑d]pyrimidin‑7(6H)‑yl}‑1‑[(5,5‑difluoro‑2‑oxopiperidin‑1‑yl)methyl]‑3‑oxopropyl)carbamate serves as an important reference standard for analytical method development and impurity profiling. The dense functionalisation of this intermediate requires precise synthetic control, and Cosperpharm ensures each batch meets strict purity specifications.

Product Parameters

Why Cosperpharm?

Complexity you can count on. The dense functionalisation—including two trifluoromethyl groups, a difluoropiperidinone, a chiral centre, and a Boc group—requires precise synthetic control. Our analytical release protocol verifies each functional group and confirms the correct stereochemistry.

DPP‑4 inhibitor expertise. Cosperpharm has extensive experience with the synthesis and quality control of DPP‑4 inhibitor intermediates, including those for gemigliptin.

Documentation for regulatory submission. Every shipment includes a COA with batch‑specific purity and characterisation data. Custom documentation for regulatory filings is available.

Reliable supply chain. From R&D quantities to commercial‑scale lots, we supply this complex intermediate with consistent quality.

Product Advantages

Multiple fluorination – Eight fluorine atoms contribute to metabolic stability and favourable pharmacokinetics.

Chiral centre – The 1S configuration is critical for biological activity.

Dual‑use – Used as both synthetic intermediate and analytical standard for HPLC.

Application Scenarios

Key synthetic intermediate for gemigliptin.

Analytical Reference Standard

Used as Gemigliptin tert‑butyl carbamate for HPLC analysis and R&D.

Process Development

Used in optimising scalable routes for gemigliptin.

Impurity Profiling

Serves as a reference standard for impurity identification.

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