(2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride

(2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride is a chiral, non-proteinogenic α-amino acid building block used in medicinal chemistry for developing fluorinated analogs of biologically active compounds. The rigid cyclohexyl backbone with geminal difluoro substitution in (2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride enhances metabolic stability and membrane permeability compared to non-fluorinated analogs. (2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride is particularly valuable for developing CNS-targeted drugs, where the enhanced lipophilicity and metabolic stability are critical for achieving adequate brain penetration and sustained activity. The compound is supplied with ≥98% purity and is intended for research and further manufacturing use only. (2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride serves as a versatile building block for incorporating the difluorocyclohexyl moiety into drug candidates, enabling the modulation of pharmacokinetic and pharmacodynamic properties.

 

Product Parameters

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Parameter	Specification
Product Name	(2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride
CAS Number	2231665-41-9
Molecular Formula	C₈H₁₄ClF₂NO₂
Molecular Weight	229.65 g/mol
Physical Form	Solid
Storage Condition	Store at room temperature, keep dry and cool

 

Why Cosperpharm?

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When your medicinal chemistry program requires fluorinated amino acid building blocks, Cosperpharm delivers (2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride with the purity and reliability that drug discovery demands.

 

Fluorination for enhanced drug properties. The geminal difluoro substitution in (2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride is specifically designed to enhance lipophilicity and metabolic stability. Any impurity or inconsistency in this building block can compromise your drug discovery program. Our analytical release protocol ensures ≥98% purity with rigorous quality control.

 

Documentation for research and development. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity data and characterization. Custom quality documentation is available upon request.

 

Flexible supply for all development stages. Cosperpharm supplies (2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride across the full range of applications—from milligram quantities for hit identification and lead optimization to larger quantities for process development and preclinical studies.

 

Technical support for fluorinated amino acid chemistry. Our team understands the unique properties of fluorinated amino acid building blocks and can provide guidance on synthesis, incorporation, and handling.

 

Global reach with transparent pricing. Cosperpharm ships to pharmaceutical companies and research institutions worldwide with full documentation included.

 

Product Advantages

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Chiral, Non-Proteinogenic α-Amino Acid

(2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride is a chiral, non-proteinogenic α-amino acid derivative with the (2S) configuration. This stereochemical purity is essential for pharmaceutical applications where enantiomeric integrity directly impacts biological activity.

 

 Gem-Difluorinated Cyclohexyl Moiety

The 4,4-difluorocyclohexyl group attached to the α-carbon of glycine features geminal difluoro substitution that enhances lipophilicity and metabolic stability compared to non-fluorinated analogs. This fluorination strategy is widely used in medicinal chemistry to improve drug-like properties.

 

 Rigid Cyclohexyl Backbone

The rigid cyclohexyl backbone of (2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride imparts conformational constraint, which can enhance target binding affinity and selectivity by reducing entropic penalties upon receptor interaction.

 

 CNS Drug Development

(2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride is particularly valuable for developing CNS-targeted drugs, where enhanced lipophilicity and metabolic stability are critical for achieving adequate brain penetration and sustained activity.

 

 High-Purity Hydrochloride Salt Form

The hydrochloride salt form offers enhanced aqueous solubility, improved crystallinity, and better handling properties compared to the free base, making (2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride more convenient for laboratory and manufacturing applications.

 

Application Scenarios

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CNS-Targeted Drug Discovery

(2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride is used in the synthesis of fluorinated analogs of biologically active compounds, particularly for developing CNS-targeted drugs.

 

Medicinal Chemistry Building

Block Serves as a versatile building block for incorporating the difluorocyclohexyl moiety into drug candidates to modulate pharmacokinetic and pharmacodynamic properties.

 

Fluorinated Analogue Synthesis

Used for preparing fluorinated analogs of biologically active compounds where enhanced metabolic stability and membrane permeability are desired.

 

Neurotransmitter Modulation

Employed in the synthesis of derivatives to modulate neurotransmitter activity.

 

Lead Optimization

The rigid, difluorinated cyclohexyl scaffold provides conformational constraint and enhanced drug-like properties for lead optimization in drug discovery programs.

 

Contact Us

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Securing (2S)-2-amino-2-(4,4-difluorocyclohexyl)acetic acid hydrochloride for your drug discovery program should be straightforward. Cosperpharm provides quality building blocks with responsive service and reliable delivery.