![β-Alanine, N-[3-(dimethylamino)propyl]-N-[3-[2-(dodecyldithio)ethoxy]-3-oxopropyl]-, 2-(dodecyldithio)ethyl ester](/upload/8820/-alanine-n-3-dimethylamino-propyl-n-3-2-dodecyldithio-ethoxy-3-oxopropyl-2-dodecyldithio-ethyl-ester-822741.webp "β-Alanine, N-[3-(dimethylamino)propyl]-N-[3-[2-(dodecyldithio)ethoxy]-3-oxopropyl]-, 2-(dodecyldithio)ethyl ester")
β-Alanine, N-[3-(dimethylamino)propyl]-N-[3-[2-(dodecyldithio)ethoxy]-3-oxopropyl]-, 2-(dodecyldithio)ethyl ester is a bioreducible ionizable lipid purpose-built for the delivery of nucleic acids into cells with elevated intracellular reducing capacity, such as activated T lymphocytes, hepatocytes, and many solid tumor types. When formulated into LNPs together with structural and shielding lipids, β-Alanine, N-[3-(dimethylamino)propyl]-N-[3-[2-(dodecyldithio)ethoxy]-3-oxopropyl]-, 2-(dodecyldithio)ethyl ester electrostatically condenses mRNA or siRNA under acidic conditions and subsequently releases the payload only after the disulfide bridges are reduced inside the target cell, minimizing premature leakage in circulation or the endolysosomal pathway. Because the lipid degradation products lack the amphiphilic character of the parent molecule, they are efficiently excreted, resulting in a favorable safety profile highlighted by low hepatotoxicity and negligible immune activation at pharmacologically effective doses. Researchers have successfully applied β-Alanine, N-[3-(dimethylamino)propyl]-N-[3-[2-(dodecyldithio)ethoxy]-3-oxopropyl]-, 2-(dodecyldithio)ethyl ester to the delivery of gene-editing ribonucleoproteins, small interfering RNA against undruggable oncogenes, and messenger RNA encoding immunostimulatory cytokines, and the lipid is increasingly referenced as a benchmark reducible carrier in comparative LNP performance studies.
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Parameter |
Specification |
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Product Name |
β-Alanine, N-[3-(dimethylamino)propyl]-N-[3-[2-(dodecyldithio)ethoxy]-3-oxopropyl]-, 2-(dodecyldithio)ethyl ester |
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CAS Number |
1624618-02-5 |
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Molecular Formula |
C39H78N2O4S4 |
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Molecular Weight |
767.3 |
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Appearance |
Colorless tolight yellowliquid |
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Purity (HPLC/ELSD) |
≥95% |
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Solubility |
Ethanol:10 mg/ml |
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Boiling Point |
760.7±60.00 °C(predicted) |
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Density |
1.023±0.06 g/cm3(predicted) |
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kPa |
9.49±0.28(predicted) |
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Storage Condition |
Store at -20℃ |
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Advantage |
Detail |
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Production Strength |
GMP-certified campus spanning 100+ mu, 3 multi-purpose workshops, 6 D-grade clean zone production lines, and 150+ reactors (20L–5000L), supporting high/low temp, anaerobic & hydrogenation; kg to ton scale production. |
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Fast Delivery |
R&D samples: one week; commercial orders: 1–2 months after payment. Express (DHL/FedEx) or air/sea freight available. |
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Global Partners |
Trusted by 30+ pharmaceutical companies in USA, Europe, India, Brazil, and Southeast Asia; long-term cooperation with generic drug manufacturers, CROs, and impurity standard distributors. |
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Licensed Exporter |
Valid drug import/export license — no compliance delays. |
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Dual Quality Grades |
Both research/pharma grade（≥98%）and high-purity impurity grade（≥99%）available to meet diverse customer needs. |
Q1: What makes this lipid respond to intracellular glutathione?
A: β-Alanine, N-[3-(dimethylamino)propyl]-N-[3-[2-(dodecyldithio)ethoxy]-3-oxopropyl]-, 2-(dodecyldithio)ethyl ester incorporates two disulfide bonds that are cleaved by the elevated glutathione levels (1–10 mM) found in the cytoplasm, causing the lipid to break into small, non-amphiphilic fragments and release its cargo.
Q2: Can it be used for tumor-specific delivery?
A: Yes. Because many cancer cells exhibit higher intracellular glutathione concentrations than normal tissues, LNPs formulated with this lipid show a degree of tumor-selective mRNA release, which can improve the therapeutic index of cytotoxic or immune-activating payloads.
β-Alanine, N-[3-(dimethylamino)propyl]-N-[3-[2-(dodecyldithio)ethoxy]-3-oxopropyl]-, 2-(dodecyldithio)ethyl ester must be stored at –20 °C in a tightly sealed, argon-flushed container that shields the contents from light. Avoid any contact with reducing agents, free thiols, or oxidizing chemicals. When aliquoting, work quickly under a stream of dry nitrogen and re-cap the stock vial immediately. The shelf life is certified as 2 years under the recommended conditions; accelerated stability data at 25 °C/60% RH are available to support clinical supply chain planning.
Take the uncertainty out of redox-responsive delivery — contact Cosperpharm today to request a sample of β-Alanine, N-[3-(dimethylamino)propyl]-N-[3-[2-(dodecyldithio)ethoxy]-3-oxopropyl]-, 2-(dodecyldithio)ethyl ester, discuss custom synthesis of dithio-lipid analogs, or secure a dedicated supply agreement for your preclinical and clinical pipeline.
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No. 2 Yangguang 3rd Road, Duodao Chemical Cycle Industrial Park, Jingmen City, Hubei Province, China
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