β-Alanine, N,N',N''-(nitrilotri-2,1-ethanediyl)tris[N-methyl-, 1,1',1''-tritridecyl ester is an advanced, biodegradable ionizable lipid used in state-of-the-art drug delivery systems. This compound, known as 304O13, is specifically designed to formulate lipid nanoparticles (LNPs) for the efficient encapsulation and delivery of nucleic acid therapeutics, such as siRNA and mRNA. The unique structure of β-Alanine, N,N',N''-(nitrilotri-2,1-ethanediyl)tris[N-methyl-, 1,1',1''-tritridecyl ester enables endosomal escape in target cells, a critical step for RNA therapeutics to reach their site of action. β-Alanine, N,N',N''-(nitrilotri-2,1-ethanediyl)tris[N-methyl-, 1,1',1''-tritridecyl ester has shown potent gene silencing activity in vivo, such as delivering Factor VII siRNA in mouse models, while demonstrating an improved toxicity profile compared to older lipid formulations. For developers of LNP-based therapies, β-Alanine, N,N',N''-(nitrilotri-2,1-ethanediyl)tris[N-methyl-, 1,1',1''-tritridecyl ester represents a powerful new tool in the delivery toolbox.
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Parameter |
Specification |
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Product Name |
β-Alanine, N,N',N''-(nitrilotri-2,1-ethanediyl)tris[N-methyl-, 1,1',1''-tritridecyl ester |
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CAS Number |
1566559-80-5 |
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Molecular Formula |
C₅₇H₁₁₄N₄O₆ |
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Molecular Weight |
951.56 g/mol |
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Purity |
>95.0% |
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Boiling point |
855.1±65.0℃(Predicted) |
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kPa |
7.98±0.50(Predicted) |
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Density |
0.943±0.06 g/cm3(Predicted) |
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Physical Form |
Liquid |
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Color |
Colorless to light yellow |
1.siRNA Therapeutic Formulation
A core component of LNPs for delivering siRNA to the liver and other tissues, enabling gene silencing for metabolic, infectious, and oncologic diseases. Demonstrated effective Factor VII knockdown in vivo.
2.mRNA Vaccine & Therapy Development
An ideal biodegradable ionizable lipid for formulating LNPs to protect and deliver mRNA for protein replacement therapies, gene editing, and next-generation vaccines.
3.Gene Editing (CRISPR) Delivery
Used to formulate LNPs for the co-delivery of Cas9 mRNA and guide RNA (gRNA) to perform in vivo gene editing.
4.LNP Formulation Screening
Used as a standard or test lipid in high-throughput screening campaigns to identify optimal LNP compositions for targeting specific cell types or achieving particular release profiles.
5.Drug Delivery Research
A research tool for studying the mechanisms of LNP-mediated endosomal escape, biodistribution, and the parameters that dictate the efficacy of RNA-based therapeutics.
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Advantage |
Detail |
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Production Strength |
GMP-certified campus spanning 100+ mu, 3 multi-purpose workshops, 6 D-grade clean zone production lines, and 150+ reactors (20L–5000L), supporting high/low temp, anaerobic & hydrogenation; kg to ton scale production. |
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Fast Delivery |
R&D samples: one week; commercial orders: 1–2 months after payment. Express (DHL/FedEx) or air/sea freight available. |
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Global Partners |
Trusted by 30+ pharmaceutical companies in USA, Europe, India, Brazil, and Southeast Asia; long-term cooperation with generic drug manufacturers, CROs, and impurity standard distributors. |
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Licensed Exporter |
Valid drug import/export license — no compliance delays. |
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Dual Quality Grades |
Both research/pharma grade（≥98%）and high-purity impurity grade（≥99%）available to meet diverse customer needs. |
Q1: What is the function of this lipid?
A: It is an ionizable cationic lipid used to formulate lipid nanoparticles (LNPs). Its role is to encapsulate nucleic acid drugs (like siRNA, mRNA) and facilitate their delivery into cells for therapeutic effect.
Q2: Is this compound hazardous?
A: Yes, it is classified with hazard statements H302 (Harmful if swallowed) and H410 (Very toxic to aquatic life with long lasting effects). It is strictly for laboratory research use and not for human or veterinary use.
Cosperpharm is your dedicated LNP lipid partner. For β-Alanine, N,N',N''-(nitrilotri-2,1-ethanediyl)tris[N-methyl-, 1,1',1''-tritridecyl ester inquiries, regulatory documentation, or GMP-grade material, email order. We guarantee a response within one business day.
Address
No. 2 Yangguang 3rd Road, Duodao Chemical Cycle Industrial Park, Jingmen City, Hubei Province, China
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