(S)-2-((tert-Butoxycarbonyl)amino)-3,3-dicyclopropylpropanoic acid

(S)-2-((tert-Butoxycarbonyl)amino)-3,3-dicyclopropylpropanoic acid is a specialized chiral building block for pharmaceutical research and development. As an N-Boc-protected derivative of 3,3-dicyclopropylalanine, (S)-2-((tert-Butoxycarbonyl)amino)-3,3-dicyclopropylpropanoic acid serves as a key intermediate in the synthesis of conformationally constrained peptide analogs and small-molecule therapeutics. The dicyclopropylalanine motif has been identified as a critical structural element that delivers both potent biological activity and metabolic stability in drug discovery programs, including the development of oral protein-protein interaction modulators. With its defined stereochemistry and robust protecting group strategy, (S)-2-((tert-Butoxycarbonyl)amino)-3,3-dicyclopropylpropanoic acid is an indispensable tool for medicinal chemists working on beyond-rule-of-5 targets and challenging synthetic campaigns requiring sterically hindered amino acid precursors.

 

 Product Parameters

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Parameter	Specification
Product Name	(S)-2-((tert-Butoxycarbonyl)amino)-3,3-dicyclopropylpropanoic acid
CAS Number	2548967-22-0
Molecular Formula	C₁₄H₂₃NO₄
Molecular Weight	269.34 g/mol
Appearance	White to off-white solid
Storage Condition	Store at room temperature

Why Cosperpharm?

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When your medicinal chemistry program demands sterically hindered, non-natural amino acid building blocks with defined stereochemistry, Cosperpharm delivers (S)-2-((tert-Butoxycarbonyl)amino)-3,3-dicyclopropylpropanoic acid with the quality and consistency that research-driven organizations require.

 

Stereochemical integrity is non-negotiable. The (S)-configuration at the α-carbon is essential for the biological activity of peptides and small molecules incorporating this scaffold. Any racemization or stereochemical erosion during synthesis compromises your downstream results. Our analytical release protocol includes chiral HPLC verification to confirm enantiomeric purity, alongside standard HPLC purity (≥98%) and identity confirmation by NMR and MS.

 

Documentation that supports your research. Every shipment includes a Certificate of Analysis (COA) with batch‑specific purity data and chromatographic traceability. Custom quality documentation and stability summaries are available upon request for customers requiring enhanced regulatory support.

 

Flexible supply from gram to kilogram scale. Cosperpharm supplies (S)-2-((tert-Butoxycarbonyl)amino)-3,3-dicyclopropylpropanoic acid across the full range of applications — from gram‑scale quantities for medicinal chemistry research and hit-to-lead optimization, to multi‑kilogram batches for preclinical development and GMP‑grade manufacturing.

 

Technical support for challenging couplings. Our process chemistry team can advise on coupling conditions for this sterically hindered amino acid, deprotection strategies, and analytical methods for detecting process‑related impurities — because we understand the synthetic challenges posed by the dicyclopropyl scaffold.

 

Global reach with transparent pricing. Cosperpharm ships to pharmaceutical companies, CROs, and academic institutions worldwide, with full customs documentation included. Volume discounts apply at larger scales, and we communicate lead times upfront.

 

Storage Conditions

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Store (S)-2-((tert-Butoxycarbonyl)amino)-3,3-dicyclopropylpropanoic acid in a tightly sealed container at room temperature. Keep the container dry, protected from moisture, and stored in a clean, well-ventilated area away from strong oxidizing agents, strong bases, and sources of ignition. The compound is stable under recommended storage conditions.

 

Handling precautions: Use in a fume hood. Wear chemical‑resistant gloves, safety goggles, and a lab coat. Avoid generating dust or aerosols. Do not eat, drink or smoke in work areas. After handling, wash hands thoroughly.

 

 

Quality Assurance at Cosperpharm

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Each batch undergoes:

 Gas chromatography (GC) – purity ≥97.0%

 Non‑aqueous titration – purity ≥97.0%

 Refractive index – confirmatory analysis

 ¹H NMR – structural verification

 Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

 

Contact Us

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Ready to secure (S)-2-((tert-Butoxycarbonyl)amino)-3,3-dicyclopropylpropanoic acid for your next medicinal chemistry campaign? Cosperpharm is here to help. Reach out to our team for pricing, availability, or technical support — we’re committed to making your research succeed.