(S)-3-((tert-Butoxycarbonyl)amino)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid

(S)-3-((tert‑Butoxycarbonyl)amino)‑4‑(5,5‑difluoro‑2‑oxopiperidin‑1‑yl)butanoic acid is a critical intermediate in the industrial synthesis of gemigliptin, a DPP‑4 inhibitor indicated for type 2 diabetes. The chiral amino acid scaffold of (S)-3-((tert‑Butoxycarbonyl)amino)‑4‑(5,5‑difluoro‑2‑oxopiperidin‑1‑yl)butanoic acid provides the essential three‑dimensional framework for DPP‑4 inhibitory activity. The S‑configuration at C3 is critical for biological activity, making enantiopurity a paramount quality attribute of (S)-3-((tert‑Butoxycarbonyl)amino)‑4‑(5,5‑difluoro‑2‑oxopiperidin‑1‑yl)butanoic acid. The compound can be used as monotherapy or in combination with other antidiabetic agents. In quality control contexts, (S)-3-((tert‑Butoxycarbonyl)amino)‑4‑(5,5‑difluoro‑2‑oxopiperidin‑1‑yl)butanoic acid serves as an important reference standard for analytical method development and impurity profiling. The combination of a Boc‑protected amino acid and a difluorinated piperidinone in (S)-3-((tert‑Butoxycarbonyl)amino)‑4‑(5,5‑difluoro‑2‑oxopiperidin‑1‑yl)butanoic acid provides synthetic chemists with a versatile building block for complex molecule construction, and Cosperpharm ensures each batch meets strict enantiomeric and chemical purity standards.

 

Product Parameters

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Parameter	Specification
Product Name	(S)-3-((tert-Butoxycarbonyl)amino)-4-(5,5-difluoro-2-oxopiperidin-1-yl)butanoic acid
CAS Number	911635-43-3
Molecular Formula	C₁₄H₂₂F₂N₂O₅
Molecular Weight	336.33 g/mol
Boiling Point	528.3±50.0 ℃
Density	1.28±0.1 g/cm3
pKa	4.32±0.10

Why Cosperpharm? – Our Competitive Advantages

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Advantage	Detail
Production Strength	GMP-certified campus spanning 100+ mu, 3 multi-purpose workshops, 6 D-grade clean zone production lines, and 150+ reactors (20L–5000L), supporting high/low temp, anaerobic & hydrogenation; kg to ton scale production.
Fast Delivery	R&D samples: one week; commercial orders: 1–2 months after payment. Express (DHL/FedEx) or air/sea freight available.
Global Partners	Trusted by 30+ pharmaceutical companies in USA, Europe, India, Brazil, and Southeast Asia; long-term cooperation with generic drug manufacturers, CROs, and impurity standard distributors.
Licensed Exporter	Valid drug import/export license — no compliance delays.
Dual Quality Grades	Both research/pharma grade（≥98%）and high-purity impurity grade（≥99%）available to meet diverse customer needs.

 

 Product Advantages

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Key gemigliptin intermediate – Essential chiral amino acid building block.

 

Chiral centre – S‑configuration critical for biological activity.

 

Boc protecting group – Enables selective deprotection under mild acidic conditions.

 

Difluoropiperidinone moiety – Contributes to metabolic stability and favourable pharmacokinetics.

 

Quality Assurance at Cosperpharm

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Each batch undergoes:

 Gas chromatography (GC) – purity ≥97.0%

 Non‑aqueous titration – purity ≥97.0%

 Refractive index – confirmatory analysis

 ¹H NMR – structural verification

 Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

 

Contact Us

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Searching for (S)-3-((tert‑Butoxycarbonyl)amino)‑4‑(5,5‑difluoro‑2‑oxopiperidin‑1‑yl)butanoic acid for your gemigliptin program? Cosperpharm is your trusted partner for chiral amino acid intermediates. Reach out today—our team is ready to support your project with quality products and technical expertise.