1,3,2-Dioxaborolane, 2,2'-(2-methyl-1,3-phenylene)bis[4,4,5,5-tetramethyl- is a dual Suzuki‑Miyaura donor used to synthesize 1,3‑diaryl‑2‑methylbenzene derivatives. The two pinacol ester groups of 1,3,2-Dioxaborolane, 2,2'-(2-methyl-1,3-phenylene)bis[4,4,5,5-tetramethyl- react independently under standard coupling conditions, enabling the construction of unsymmetrical teraryl cores by controlling stoichiometry and catalyst. In materials chemistry, 1,3,2-Dioxaborolane, 2,2'-(2-methyl-1,3-phenylene)bis[4,4,5,5-tetramethyl- serves as a rigid, conjugated building block for covalent organic frameworks and macrocyclic receptors. Cosperpharm ensures that 1,3,2-Dioxaborolane, 2,2'-(2-methyl-1,3-phenylene)bis[4,4,5,5-tetramethyl- is supplied with minimal mono‑boronate or de‑borylated impurities, guaranteeing stoichiometric precision in two‑fold couplings.
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Parameter |
Specification |
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Product Name |
1,3,2-Dioxaborolane, 2,2'-(2-methyl-1,3-phenylene)bis[4,4,5,5-tetramethyl- |
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CAS Number |
849402-14-8 |
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Molecular Formula |
C₁₉H₃₀B₂O₄ |
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Molecular Weight |
344.06 g/mol |
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Appearance |
White to off-white crystalline powder |
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Melting Point |
~130–135 °C (typical) |
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Purity (HPLC) |
≥98.0% |
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Solubility |
Soluble in THF, DMF, dichloromethane; sparingly soluble in methanol, water |
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Storage Condition |
2–8 °C, sealed under inert atmosphere, protect from moisture |
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Shelf Life |
24 months under recommended conditions |
1. Two Boronate Handles, One Core – Enables one‑pot or sequential double Suzuki couplings for rapid complexity generation.
2. Symmetrical Structure with Methyl Bias – The 2‑methyl group creates a small steric difference that can be exploited for stepwise coupling.
3. High‑Melting Solid – Crystalline, non‑hygroscopic, and easy to handle on the open bench for short periods.
4. Predictable Reactivity – The pinacol esters react reliably with Pd(PPh₃)₄ or Pd(dppf)Cl₂ under standard conditions.
5. Bulk Supply Consistency – Lot‑to‑lot reproducibility suitable for process validation and GMP‑adjacent campaigns.
Q1: Can I perform a selective mono‑coupling with this di‑boronate?
A: Yes, using 1.0 equivalent of an aryl bromide with a bulky ligand such as SPhos often leads to preferential mono‑substitution. The steric effect of the 2‑methyl group aids selectivity.
Q2: What are the standard double‑coupling conditions?
A: Use 2.5 equivalents of aryl bromide, 4 mol% Pd(PPh₃)₄, and aqueous K₂CO₃ in DME at 85 °C for 18 h.
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Advantage |
Detail |
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Production Strength |
GMP-certified campus spanning 100+ mu, 3 multi-purpose workshops, 6 D-grade clean zone production lines, and 150+ reactors (20L–5000L), supporting high/low temp, anaerobic & hydrogenation; kg to ton scale production. |
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Fast Delivery |
R&D samples: one week; commercial orders: 1–2 months after payment. Express (DHL/FedEx) or air/sea freight available. |
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Global Partners |
Trusted by 30+ pharmaceutical companies in USA, Europe, India, Brazil, and Southeast Asia; long-term cooperation with generic drug manufacturers, CROs, and impurity standard distributors. |
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Licensed Exporter |
Valid drug import/export license — no compliance delays. |
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Dual Quality Grades |
Both research/pharma grade（≥98%）and high-purity impurity grade（≥99%）available to meet diverse customer needs. |
For a quote on this versatile di‑boronate, or to request a sample for a feasibility study, reach out to Cosperpharm’s specialty chemical division — we can deliver a small‑quantity evaluation pack and discuss tailored supply agreements for your production needs.
Address
No. 2 Yangguang 3rd Road, Duodao Chemical Cycle Industrial Park, Jingmen City, Hubei Province, China
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