1-((4'-chloro-5,5-dimethyl-3,4, 5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride

1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride is a pivotal pharmaceutical intermediate widely recognized for its role in the synthesis of Venetoclax (ABT-199), a first-in-class BCL-2 inhibitor approved for the treatment of chronic lymphocytic leukemia (CLL) and other hematological malignancies. As a conformationally constrained molecule, 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride features a rigid tetrahydrobiphenyl scaffold that pre-organizes the functional groups in three-dimensional space, a property that is highly valued in medicinal chemistry for reducing entropic penalties upon target binding. 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride is supplied as a crystalline solid with purity specifications typically exceeding 98% (HPLC). In quality control and research contexts, 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride serves as an essential reference standard for impurity profiling, analytical method development, and process optimization for Venetoclax manufacturing. The compound demonstrates the versatility of the piperazine-containing scaffold in drug discovery, with the core structure also being investigated for applications in BTK, PI3K, and JAK-2 inhibitor synthesis.

Product Parameters

Application

1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride is an intermediate used for the preparation of Venetoclax. It is a potent and selective BCL-2 inhibitor with strong anti-tumor activity, while preserving platelets. Venetoclax is used to treat chronic lymphocytic leukemia cells and estrogen receptor-positive breast cancer.

Product Quality Assurance

Cosperpharm has established a comprehensive quality assurance system for 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride that meets the rigorous expectations of pharmaceutical intermediate manufacturing:

Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: HPLC purity verification (≥98%), appearance verification (light beige crystalline solid), water content determination (Karl Fischer), residual solvent analysis (GC), and identity confirmation.

Full batch traceability. From raw material procurement through synthesis, purification, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with sufficient retention samples maintained.

Documentation ready for regulatory submission. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, a Safety Data Sheet (SDS), and customs documentation. DMF-ready documentation packages are available upon request.

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm's manufacturing, quality control, and documentation facilities.

Contact Us

Securing 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride for your Venetoclax manufacturing program or pharmaceutical research should be straightforward. Cosperpharm makes it simple with high-quality intermediates, comprehensive documentation, and responsive technical support. Contact us today to discuss your requirements—we're here to help you succeed.