2-amino-2-methylhexanoicacid hydrochloride

2-Amino-2-methylhexanoic acid hydrochloride is a versatile non-natural amino acid building block widely employed in peptide synthesis, medicinal chemistry, and pharmaceutical research. As anα,α-disubstituted amino acid, 2-Amino-2-methylhexanoic acid hydrochloride features a methyl group and a butyl side chain at theα-carbon, creating a sterically hindered environment that induces significant conformational constraint when incorporated into peptide sequences. The hydrochloride salt form of 2-Amino-2-methylhexanoic acid hydrochloride provides excellent water solubility and handling characteristics, making it the preferred form for most synthetic and analytical applications. 2-Amino-2-methylhexanoic acid hydrochloride serves as a key building block in the synthesis of sterically constrained peptides, peptidomimetics, and biologically active compounds, with applications spanning chemistry research (as a building block for complex molecule synthesis), biology (as a precursor in amino acid metabolism studies), and plant science (as an elicitor inducing resistance against biotic and abiotic stresses). The uniqueα,α-disubstituted architecture of 2-Amino-2-methylhexanoic acid hydrochloride imparts distinct chemical and biological properties that differentiate it from natural amino acids and other non-natural analogs.

Product Parameters

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Product Advantages

α,α-Disubstituted Amino Acid for Conformational Constraint

2-Amino-2-methylhexanoic acid hydrochloride features a uniqueα,α-disubstituted architecture with a methyl group and a butyl side chain at theα-carbon. When incorporated into peptides, this sterically hindered structure restricts backbone flexibility and promotes the formation of stable secondary structures such as helices and turns—a property highly valued in peptidomimetic design and the development of conformationally constrained bioactive peptides.

Freely Soluble Hydrochloride Salt Form

The hydrochloride salt form of 2-Amino-2-methylhexanoic acid hydrochloride provides excellent water solubility and handling characteristics. The crystalline solid is convenient to weigh and handle, and the salt form offers enhanced long-term storage stability compared to the free amino acid.

Versatile Building Block for Multiple Applications

2-Amino-2-methylhexanoic acid hydrochloride serves diverse applications across multiple scientific disciplines: in chemistry as a building block for complex molecule synthesis; in biology as a precursor in amino acid metabolism studies; and in plant science as an elicitor inducing resistance against biotic and abiotic stresses. This versatility makes it a valuable addition to any research laboratory's building block inventory.

High-Purity, Well-Characterized Building Block

Cosperpharm supplies 2-Amino-2-methylhexanoic acid hydrochloride at≥95% purity with full analytical characterization including HPLC purity verification and identity confirmation. The compound's well-characterized physical properties support reliable method development and scale-up.

Non-Natural Amino Acid for Drug Discovery

As a non-natural amino acid, 2-Amino-2-methylhexanoic acid hydrochloride enables the exploration of chemical space beyond the 20 canonical amino acids. The unique structural configuration of this compound imparts distinct chemical and biological properties that differentiate it from natural amino acids and other non-natural analogs.

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Ready to source 2-Amino-2-methylhexanoic acid hydrochloride for your peptide synthesis program, medicinal chemistry research, or process development project? Cosperpharm is here to help—contact us today to discuss your requirements, request a quote, or arrange a technical consultation.