![2'-METHYL[1,1'-BIPHENYL]-3-OL](/upload/8820/2-methyl-1-1-biphenyl-3-ol-13589.webp "2'-METHYL[1,1'-BIPHENYL]-3-OL")
2'-METHYL[1,1'-BIPHENYL]-3-OL is a versatile intermediate utilized in the synthesis of liquid crystals, non‑steroidal anti‑inflammatory drugs (NSAIDs), and functional materials. The phenolic group of 2'-METHYL[1,1'-BIPHENYL]-3-OL can be readily etherified, esterified, or converted to a sulfonate to enable nickel‑ or copper‑mediated coupling at the C–O position. Because 2'-METHYL[1,1'-BIPHENYL]-3-OL is a well‑characterized solid, it can be incorporated into multi‑step sequences without the handling difficulties associated with oily phenol intermediates. Medicinal chemists have used 2'-METHYL[1,1'-BIPHENYL]-3-OL to generate libraries of biphenyl‑based enzyme inhibitors where the methyl group improves potency by occupying a small hydrophobic pocket.
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Parameter |
Specification |
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Product Name |
2'-METHYL[1,1'-BIPHENYL]-3-OL |
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CAS Number |
106912-94-1 |
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Molecular Formula |
C₁₃H₁₂O |
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Molecular Weight |
184.23 g/mol |
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Appearance |
Solid, ranging from off-white to yellow |
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Boiling Point |
319.5±21.0℃ |
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Purity (GC/HPLC) |
≥98.0% |
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Solubility |
Soluble in dichloromethane, ethyl acetate, methanol; slightly soluble in water |
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Storage Condition |
Store at room temperature, tightly sealed, protected from light |
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Shelf Life |
36 months under recommended conditions |
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Advantage |
Detail |
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Production Strength |
GMP-certified campus spanning 100+ mu, 3 multi-purpose workshops, 6 D-grade clean zone production lines, and 150+ reactors (20L–5000L), supporting high/low temp, anaerobic & hydrogenation; kg to ton scale production. |
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Fast Delivery |
R&D samples: one week; commercial orders: 1–2 months after payment. Express (DHL/FedEx) or air/sea freight available. |
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Global Partners |
Trusted by 30+ pharmaceutical companies in USA, Europe, India, Brazil, and Southeast Asia; long-term cooperation with generic drug manufacturers, CROs, and impurity standard distributors. |
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Licensed Exporter |
Valid drug import/export license — no compliance delays. |
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Dual Quality Grades |
Both research/pharma grade（≥98%）and high-purity impurity grade（≥99%）available to meet diverse customer needs. |
1. Liquid Crystal Intermediate
The biphenyl core with a polar phenol and a methyl group is used in the formulation of nematic and smectic liquid crystals.
2. NSAID Analog Synthesis
Serves as a precursor to biphenylacetic acid‑based anti‑inflammatory agents.
3. Polymer Antioxidant
The hindered phenol structure is incorporated into polymer additives to prevent thermal oxidation.
4. Biphenyl Ligand Construction
Used to prepare phosphine and N‑heterocyclic carbene ligands bearing a biphenyl backbone.
5. Antimicrobial Agent R&D
Functionalized biphenyl‑3‑ols have shown activity against Gram‑positive bacterial strains.
Each batch undergoes:
● Gas chromatography (GC) – purity ≥97.0%
● Non‑aqueous titration – purity ≥97.0%
● Refractive index – confirmatory analysis
● ¹H NMR – structural verification
● Appearance – colorless to light yellow to light orange clear liquid
A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.
Need a dependable source for this substituted biphenol building block? Connect with Cosperpharm’s fine chemical supply coordinator — we can confirm stock levels, provide a quote, and dispatch samples for your analytical group within a single business day.
Address
No. 2 Yangguang 3rd Road, Duodao Chemical Cycle Industrial Park, Jingmen City, Hubei Province, China
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