3,3',3'',3'''-(((Methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfa nyl)ethyl)propanamide)

3,3',3'',3'''-(((Methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfanyl)ethyl)propanamide) is a highly selective ionizable lipid designed for extrahepatic nucleic acid delivery, with a remarkable preference for lung tissue. Through a mechanism involving the selective adsorption of specific plasma proteins like fibrinogen β/γ chain, 3,3',3'',3'''-(((Methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfanyl)ethyl)propanamide) -based LNPs achieve efficient and selective transgene expression in pulmonary endothelial cells and macrophages. For researchers developing targeted therapies for hereditary pulmonary diseases, 3,3',3'',3'''-(((Methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfanyl)ethyl)propanamide) represents a critical tool. In preclinical studies, 3,3',3'',3'''-(((Methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfanyl)ethyl)propanamide) has demonstrated potent lung-targeting capabilities, enabling functional gene editing in over 30% of endothelial cells with minimal off-target expression in the liver or spleen.

Product Parameters

Quality Assurance at Cosperpharm

Each batch undergoes:

l Gas chromatography (GC) – purity ≥97.0%

l Non‑aqueous titration – purity ≥97.0%

l Refractive index – confirmatory analysis

l ¹H NMR – structural verification

l Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

Application Scenarios

1. Lung-Selective mRNA Delivery

The core application for 3,3',3'',3'''-(((Methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfanyl)ethyl)propanamide) is formulating LNPs that deliver mRNA payloads efficiently and specifically to lung tissue, avoiding systemic exposure.

2.Gene Therapy for Hereditary Lung Diseases

Used in preclinical models of pulmonary lymphangioleiomyomatosis (LAM) to deliver functional Tsc2 mRNA and restore tumor suppressor function, offering a potential therapeutic avenue for patients.

3.Pulmonary Endothelial Cell Gene Editing

Enables precise genome editing in lung endothelial cells. In Cre/LoxP models, it achieved 33.6% transfection in these target cells, a key step for developing therapies for pulmonary vascular diseases.

4. Lung-Specific mRNA Vaccine Development

The unique targeting ability of 3,3',3'',3'''-(((Methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfanyl)ethyl)propanamide) makes it an excellent candidate for creating mRNA vaccines that generate strong mucosal immunity in the respiratory tract against pulmonary pathogens.

5.Protein Corona Research

Acts as a unique research tool to study how the physicochemical properties of LNPs (particularly tail structures) influence selective protein adsorption, which can be harnessed for extrahepatic delivery.

FAQ

Q1: What is 3,3',3'',3'''-(((Methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfanyl)ethyl)propanamide) used for?

A: It is an ionizable cationic lipid specifically formulated for lung-selective mRNA delivery. It is used in the development of gene therapies for hereditary lung diseases, pulmonary mRNA vaccines, and lung cancer models where precise, high-efficiency transfection of lung endothelial cells is required.

Q2: How does 3,3',3'',3'''-(((Methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfanyl)ethyl)propanamide) achieve lung targeting?

A: Upon intravenous injection, 3,3',3'',3'''-(((Methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfanyl)ethyl)propanamide) nanoparticles selectively bind to specific plasma proteins, forming a “protein corona.” This corona guides the particles to accumulate and be taken up by cells in the lungs rather than the liver.

Contact Us

Whether you‘re screening lung-selective LNPs or scaling up for preclinical efficacy studies, let Cosperpharm be your supply partner for 3,3',3'',3'''-(((Methylazanediyl)bis(propane-3,1-diyl))bis(azanetriyl))tetrakis(N-(2-(dodecyldisulfanyl)ethyl)propanamide) . Reach out for technical data sheets, a custom quote, or to discuss your program’s needs. We‘re ready to support your breakthrough discovery from start to finish.