5,6,7,8-tetrahydro-2,4-bis(trifluoroMethyl)-Pyrido[3,4-d]pyriMidine hydrochloride

5,6,7,8‑Tetrahydro‑2,4‑bis(trifluoromethyl)pyrido[3,4‑d]pyrimidine Hydrochloride is a critical intermediate in the industrial synthesis of gemigliptin, a DPP‑4 inhibitor indicated for type 2 diabetes. The pyridopyrimidine core of 5,6,7,8‑Tetrahydro‑2,4‑bis(trifluoromethyl)pyrido[3,4‑d]pyrimidine Hydrochloride provides the essential heterocyclic framework for DPP‑4 inhibitory activity. Gemigliptin can be used as monotherapy or in combination with metformin. The two trifluoromethyl groups of 5,6,7,8‑Tetrahydro‑2,4‑bis(trifluoromethyl)pyrido[3,4‑d]pyrimidine Hydrochloride enhance metabolic stability and contribute to the favourable pharmacokinetic profile of the final drug. In quality control contexts, 5,6,7,8‑Tetrahydro‑2,4‑bis(trifluoromethyl)pyrido[3,4‑d]pyrimidine Hydrochloride serves as an important reference standard for analytical method development and impurity profiling. The hydrochloride salt form of 5,6,7,8‑Tetrahydro‑2,4‑bis(trifluoromethyl)pyrido[3,4‑d]pyrimidine Hydrochloride offers improved water solubility and handling characteristics compared to the free base.

 
Product Parameters

Parameter	Specification
Product Name	5,6,7,8-Tetrahydro-2,4-bis(trifluoromethyl)pyrido[3,4-d]pyrimidine Hydrochloride
CAS Number	911636-86-7
Molecular Formula	C₉H₈ClF₆N₃
Molecular Weight	307.62 g/mol

 

Why Cosperpharm?

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When your gemigliptin synthesis requires reliable fluorinated heterocyclic intermediates, Cosperpharm delivers 5,6,7,8‑Tetrahydro‑2,4‑bis(trifluoromethyl)pyrido[3,4‑d]pyrimidine Hydrochloride with the quality and consistency that pharmaceutical manufacturing demands.

 

Foundation for DPP‑4 inhibitor synthesis. The pyridopyrimidine core is the structural foundation of gemigliptin. Any impurity in this key intermediate will carry through to the final API. Our analytical release protocol includes HPLC purity verification and structural confirmation.

 

Salt form advantages. The hydrochloride salt offers enhanced water solubility, crystallinity, and handling characteristics.

 

Documentation for regulatory submission. Every shipment includes a COA with batch‑specific purity and characterisation data. Custom documentation is available upon request.

 

Reliable supply chain. From R&D quantities to commercial‑scale lots, we supply consistent quality.

 

Product Advantages

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Key gemigliptin intermediate – Essential heterocyclic building block for gemigliptin.

 

Dual trifluoromethyl substitution – Enhances metabolic stability and activity.

 

Hydrochloride salt – Provides enhanced water solubility and crystallinity.

 

Versatile heterocyclic scaffold – Privileged structure in medicinal chemistry.

 

 Product Quality Assurance

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Cosperpharm ensures rigorous QC for this compound. Each batch is tested for HPLC purity (≥95%), structural confirmation, and residual solvents. A COA accompanies every shipment. Full traceability is maintained.

 

Contact Us

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Need 5,6,7,8‑Tetrahydro‑2,4‑bis(trifluoromethyl)pyrido[3,4‑d]pyrimidine Hydrochloride for your gemigliptin program? Cosperpharm is your trusted source for high‑quality fluorinated heterocyclic intermediates. Reach out today—we‘re ready to support your research, development, and production needs.