7-hydroxy-7-(4-((1-methylpiperidine-4-carbonyl)oxy)butyl)tridecane-1,11-diyl bis(2-hexyldecanoate)

7-hydroxy-7-(4-((1-methylpiperidine-4-carbonyl)oxy)butyl)tridecane-1,11-diyl bis(2-hexyldecanoate) is an ionizable lipid widely used in the synthesis of lipid nanoparticles (LNPs) for delivering mRNA and other nucleic acid payloads. The structure of 7-hydroxy-7-(4-((1-methylpiperidine-4-carbonyl)oxy)butyl)tridecane-1,11-diyl bis(2-hexyldecanoate) includes a central tertiary alcohol and two branched 2‑hexyldecanoate tails that provide optimal hydrophobic volume for efficient mRNA encapsulation and endosomal escape. Notably, 7-hydroxy-7-(4-((1-methylpiperidine-4-carbonyl)oxy)butyl)tridecane-1,11-diyl bis(2-hexyldecanoate) has a reported pKa of 6.75, which is nearly ideal for endosomal escape, as it ensures the lipid remains neutral at physiological pH (7.4) but becomes positively charged in the acidic endosome (pH 5.0–6.0). This precise pKa tuning enables 7-hydroxy-7-(4-((1-methylpiperidine-4-carbonyl)oxy)butyl)tridecane-1,11-diyl bis(2-hexyldecanoate) to efficiently release its cargo into the cytoplasm, making it a highly effective component in mRNA vaccine and gene therapy platforms.

Product Parameters

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Product Advantages

1. Optimized pKa (6.75) for Endosomal Escape: With a pKa of 6.75, 7-hydroxy-7-(4-((1-methylpiperidine-4-carbonyl)oxy)butyl)tridecane-1,11-diyl bis(2-hexyldecanoate) remains neutral in the bloodstream (pH 7.4) but becomes protonated within the acidic endosome (pH 5.0–6.0), triggering membrane destabilization and efficient cytoplasmic release of the nucleic acid cargo. This precise pKa is widely considered optimal for endosomal escape.

2. Branched, Saturated Tails for Enhanced Stability: The two 2‑hexyldecanoate tails are branched and fully saturated. Branching lowers the melting temperature (Tm) of the lipid, preventing crystallization and maintaining fluidity at physiological temperatures. The saturated nature of these tails resists oxidative degradation, giving 7-hydroxy-7-(4-((1-methylpiperidine-4-carbonyl)oxy)butyl)tridecane-1,11-diyl bis(2-hexyldecanoate) superior chemical stability compared to unsaturated lipids.

3. Well‑Characterized in Polymer‑Lipid Hybrid Systems: 7-hydroxy-7-(4-((1-methylpiperidine-4-carbonyl)oxy)butyl)tridecane-1,11-diyl bis(2-hexyldecanoate) has been validated in polymer‑lipid hybrid nanoparticles for the delivery of large plasmid DNA (pDNA) in vitro, demonstrating its versatility beyond standard mRNA formulations.

4. Single Tertiary Amine Headgroup for Predictable Ionization: Unlike more complex lipids with multiple ionizable centers, 7-hydroxy-7-(4-((1-methylpiperidine-4-carbonyl)oxy)butyl)tridecane-1,11-diyl bis(2-hexyldecanoate) features a single methylpiperidine headgroup, providing a sharp, predictable pH‑dependent ionization profile that simplifies formulation development.

5. Saturated 2‑Hexyldecanoate Tails for Long Shelf Life: The use of saturated, branched 2‑hexyldecanoate esters eliminates the risk of autoxidation and lipid peroxidation, ensuring that 7-hydroxy-7-(4-((1-methylpiperidine-4-carbonyl)oxy)butyl)tridecane-1,11-diyl bis(2-hexyldecanoate) remains stable during long‑term storage without the need for antioxidants or special handling.

Storage Conditions

Store 7-hydroxy-7-(4-((1-methylpiperidine-4-carbonyl)oxy)butyl)tridecane-1,11-diyl bis(2-hexyldecanoate) in a tightly sealed container under inert atmosphere (nitrogen or argon) at –20 °C for long‑term storage (3 years) or at 2–8 °C for short‑term storage (2 years). Keep the container dry, protected from light, and away from strong oxidizing agents. The compound is stable as a solid under recommended conditions.

Shelf life: 3 years when stored as a powder at –20 °C; 2 years when stored at 4 °C. Once reconstituted in solvent, the solution should be stored at –80 °C for up to 6 months.

Handling precautions: Use only in a well‑ventilated area or fume hood. Wear chemical‑resistant gloves, safety goggles, and a lab coat. Avoid generating dust. After handling, wash hands thoroughly. Refer to the Safety Data Sheet (SDS) for complete safety information.

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Need 7-hydroxy-7-(4-((1-methylpiperidine-4-carbonyl)oxy)butyl)tridecane-1,11-diyl bis(2-hexyldecanoate) for your next mRNA delivery project? Cosperpharm makes ordering straightforward: get an instant pricing estimate, request bulk quantities, or ask for our latest batch analysis. Reach out via our online form or send an email — we’ll provide a formal quote within one business day, with shipping options to any global destination.