Boc-Lys(Boc)-ONp

Boc-Lys(Boc)-ONp is an essential protected lysine derivative widely employed in contemporary peptide synthesis and biochemical research. As a specialized building block, Boc-Lys(Boc)-ONp enables the incorporation of lysine residues into peptides while maintaining orthogonal protection of both amino groups. Boc-Lys(Boc)-ONp is extensively used in solid-phase peptide synthesis as a protecting group for lysine residues. The activated 4-nitrophenyl ester of Boc-Lys(Boc)-ONp facilitates efficient coupling reactions without the need for additional activating reagents, streamlining peptide assembly workflows. Boc-Lys(Boc)-ONp is also employed in dendrimer preparation and bioconjugation applications. The compound's dual Boc protection strategy of Boc-Lys(Boc)-ONp allows for selective deprotection of both amino groups under acidic conditions, enabling the synthesis of branched peptides, multiple antigenic peptides (MAPs), and other complex architectures.

Product Parameters

Why Cosperpharm?

Dual protection for complex peptide architectures. Lysine contains two amino groups — both must be protected during peptide synthesis to prevent unwanted side reactions. Boc-Lys(Boc)-ONp provides dual Boc protection on both the α- and ε-amino groups, allowing for the synthesis of branched peptides, multiple antigenic peptides, and dendrimers with precise control.

Activated ester for efficient coupling. The 4-nitrophenyl ester of Boc-Lys(Boc)-ONp serves as a highly activated leaving group, facilitating rapid and high-yielding peptide bond formation without the need for additional activating reagents. This simplifies peptide assembly workflows and reduces reaction byproducts.

Purity that ensures peptide fidelity. At ≥98% purity (HPLC), Boc-Lys(Boc)-ONp delivers the consistency required for reliable peptide synthesis. Every batch is characterized to ensure your peptide assembly proceeds without compromising sequence fidelity.

Documentation that supports regulatory and research needs. Every shipment includes a Certificate of Analysis (COA) with batch-specific HPLC purity, melting point, and optical rotation data. For customers preparing regulatory submissions, DMF-ready documentation, stability summaries, and custom quality agreements are available upon request.

Flexible supply across all scales. Cosperpharm supplies Boc-Lys(Boc)-ONp from 500mg–1g research quantities for peptide library synthesis to bulk quantities for commercial peptide manufacturing and dendrimer production. R&D samples ship within 5–7 business days; bulk orders ship within 2–3 weeks.

Technical support for peptide chemists. Our process chemistry team can advise on coupling strategies, deprotection conditions, and compatibility with various peptide synthesis platforms — because we have worked extensively with this protected lysine derivative across multiple manufacturing campaigns.

Product Advantages

Lysine presents a unique challenge in peptide synthesis due to its two amino groups. Boc-Lys(Boc)-ONp addresses this with Boc protection on both the α-amino and ε-amino groups, preventing unwanted side reactions and enabling the synthesis of complex peptide architectures.

Activated 4-Nitrophenyl Ester for Efficient Coupling

The 4-nitrophenyl ester of Boc-Lys(Boc)-ONp is a highly activated leaving group that facilitates rapid and high-yielding peptide bond formation. This eliminates the need for additional activating reagents (e.g., HOBt, DCC), simplifying peptide assembly and reducing byproducts.

Orthogonal Deprotection Strategy

The dual Boc groups on Boc-Lys(Boc)-ONp can be selectively removed under acidic conditions (TFA), enabling the controlled deprotection of one or both amino groups for the synthesis of branched and cyclic peptides.

Chromophore for UV Monitoring

The 4-nitrophenyl ester moiety provides a chromophore for UV detection during HPLC purification and analysis, facilitating quality control and monitoring of coupling reactions.

Versatile Applications Across Peptide Chemistry

Boc-Lys(Boc)-ONp is used in solid-phase peptide synthesis, dendrimer preparation, bioconjugation, and drug delivery systems — demonstrating the exceptional versatility of this protected lysine derivative.

Storage Conditions

Store Boc-Lys(Boc)-ONp in a tightly sealed container at 2-8°C. Keep the container dry, protected from light, and stored in a clean, well-ventilated area away from strong oxidizing agents, strong acids, and strong bases. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Shelf life: 3 years when stored at −20°C in a sealed container; 2 years when stored at 2-8 °C. Stability summaries are available upon request.

Handling precautions: Use in a fume hood. Wear chemical-resistant gloves, safety goggles, and a lab coat. Avoid generating dust or aerosols. Do not eat, drink or smoke in work areas. After handling, wash hands thoroughly. Refer to the Safety Data Sheet (SDS) for complete safety information.

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