Dotinurad is a pivotal pharmaceutical active ingredient and research compound in the treatment of hyperuricemia and gout, functioning as a highly selective urate transporter 1 (URAT1) inhibitor. As the first-in-class phenol derivative with a 1,1-dioxo-1,2-dihydro-3H-1,3-benzothiazole scaffold, Dotinurad demonstrates remarkable inhibitory activity on uric acid uptake by primary human renal proximal tubule epithelial cells with minimal off-target effects . Dotinurad selectively targets URAT1 over other organic anion transporters, providing a targeted approach to reducing serum urate levels while avoiding the mitochondrial toxicity concerns associated with older uricosuric agents like benzbromarone . In pharmacokinetic studies, Dotinurad has shown favorable bioavailability and dose-proportional exposure, making it a promising therapeutic option for patients with chronic kidney disease who require urate-lowering therapy . The compound's unique structural features—a dichlorohydroxyphenyl ketone linked to a benzothiazole dioxide—underpin its potent URAT1 inhibitory activity, which has been validated in both in vitro and in vivo models including cynomolgus monkeys . Dotinurad represents a significant advancement in gout pharmacotherapy, providing a safer and more effective alternative for managing hyperuricemia.
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Product Name |
Dotinurad |
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–20°C (long-term, desiccated); 0°C (short-term) |
Dotinurad is an effective selective urate reabsorption inhibitor characterized by its increasing therapeutic efficacy as plasma urate levels decrease.
Dotinurad reduces urinary uric acid levels in the blood by inhibiting uric acid transporters, thereby decreasing renal reabsorption of uric acid.
Aminothiol (152) reacts with formaldehyde hydrate to yield dihydropyridazol-153. Acid 154 is converted into acyl chloride 155. Dihydropyridazol-153 is then condensed with the acid-based chloride 155 to form amide 156. The thiazole moiety is oxidized using mCPBA. Under the influence of lithium chloride, the methyl ether group is removed, yielding multitodine.
The path to reliable URAT1 research begins with dependable compound quality—and Cosperpharm delivers. We invite you to reach out to discuss how we can support your research with Dotinurad of uncompromising purity and traceability.
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