Fmoc-5-Hydroxy-Nva(TBDPS)-OH

Fmoc-5-Hydroxy-Nva(TBDPS)-OH is a specialized Fmoc-protected amino acid building block designed for the introduction of hydroxy-norvaline residues into peptide sequences via solid-phase peptide synthesis (SPPS). The compound features a TBDPS-protected hydroxyl group at the C5 position of the norvaline side chain, providing orthogonal protection that enables selective deprotection and functionalization during peptide assembly. Fmoc-5-Hydroxy-Nva(TBDPS)-OH is commonly employed in structural biology for the design of modified peptides and proteins that mimic natural structures. The compound‘s ability to introduce hydroxyl groups into peptide chains allows for the exploration of hydrogen bonding and other interactions within protein structures. As a versatile building block, Fmoc-5-Hydroxy-Nva(TBDPS)-OH supports the synthesis of complex peptide chains in both research and pharmaceutical development settings. The compound’s high purity (≥98% by HPLC) and well-characterized physical properties make it a reliable reagent for demanding peptide synthesis applications.

Product Parameters

Why Cosperpharm?

Orthogonal protection for complex peptide assembly. The TBDPS group in Fmoc-5-Hydroxy-Nva(TBDPS)-OH provides a robust, acid-stable protecting group for the side-chain hydroxyl that can be selectively removed under mild conditions without affecting the Fmoc group or other acid-labile protecting groups. This orthogonal protection strategy is essential for synthesizing complex, multi-functionalized peptides. Our analytical release protocol includes HPLC purity verification (≥98%), appearance verification, and identity confirmation—because your peptide synthesis success depends on the quality of this specialized building block.

Documentation that supports regulatory submission. Every shipment includes a Certificate of Analysis (COA) with batch-specific HPLC purity and characterization data. Stability summaries and custom quality agreements are available upon request for customers preparing regulatory filings for peptide-based therapeutics.

Flexible supply across all development stages. Cosperpharm supplies Fmoc-5-Hydroxy-Nva(TBDPS)-OH across the full range of applications—from gram-scale quantities for research and method development, to larger batches for process validation and commercial peptide manufacturing. R&D samples ship within 5–7 business days; bulk orders ship within 2–3 weeks.

Technical support for peptide synthesis. Our process chemistry team can advise on TBDPS deprotection conditions, Fmoc removal protocols, and analytical methods for detecting process-related impurities.

Global reach with transparent pricing. Cosperpharm ships to pharmaceutical manufacturers, CROs, and research laboratories worldwide, with full customs documentation included.

Product Advantages

The TBDPS (tert-butyldiphenylsilyl) group provides robust protection for the side-chain hydroxyl group. This bulky silyl ether is stable under standard Fmoc-SPPS conditions and can be selectively cleaved under mild acidic conditions (TFA or HF·pyridine) without affecting the Fmoc group or other acid-labile protecting groups.

 Introduction of Hydroxy-Norvaline Residues

Fmoc-5-Hydroxy-Nva(TBDPS)-OH enables the introduction of 5-hydroxy-norvaline residues into peptide sequences. The hydroxyl group provides a handle for hydrogen bonding, post-synthetic modification, or conjugation to other molecules.

 Non-Proteinogenic Amino Acid Scaffold

As a non-proteinogenic amino acid derivative, Fmoc-5-Hydroxy-Nva(TBDPS)-OH expands the chemical space available for peptide drug discovery. The norvaline backbone provides a five-carbon scaffold that differs from natural amino acids, offering unique conformational and pharmacological properties.

 Fmoc SPPS Compatibility

The Fmoc protecting group ensures full compatibility with standard Fmoc-SPPS protocols. The compound can be incorporated into growing peptide chains using standard coupling conditions, making it accessible to researchers already equipped for Fmoc-SPPS.

 High Purity for Demanding Applications

Cosperpharm supplies Fmoc-5-Hydroxy-Nva(TBDPS)-OH at ≥98% purity (HPLC), ensuring reliable performance in peptide synthesis and analytical applications.

 Structural Biology and Protein Engineering Applications

The compound is utilized in structural biology for the design of modified peptides and proteins that mimic natural structures. The ability to introduce hydroxyl groups into peptide chains allows for the exploration of hydrogen bonding and other interactions within protein structures.

Quality Assurance at Cosperpharm

Each batch undergoes:

 Gas chromatography (GC) – purity ≥97.0%

 Non‑aqueous titration – purity ≥97.0%

 Refractive index – confirmatory analysis

 ¹H NMR – structural verification

 Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

Contact Us

Looking for Fmoc-5-Hydroxy-Nva(TBDPS)-OH with guaranteed purity and documented quality for your peptide synthesis project? Cosperpharm delivers. Get in touch with our team for a quote, technical datasheets, or to discuss your specific requirements.