Fmoc-Arg(Pmc)-OH

Fmoc-Arg(Pmc)-OH is an excellent derivative for the introduction of arginine residues in Fmoc solid-phase peptide synthesis. The Pmc protecting group on Fmoc-Arg(Pmc)-OH offers a deprotection profile that is roughly equivalent in acid lability to tert-butyl-based protecting groups, allowing simultaneous removal during TFA-mediated cleavage from Wang or Rink amide resins. Fmoc-Arg(Pmc)-OH is particularly recommended for use in the synthesis of peptides containing both arginine and tryptophan, where it should be used in conjunction with Fmoc-Trp(Boc)-OH to minimize side reactions. As one of the most popular arginine derivatives in Fmoc SPPS, Fmoc-Arg(Pmc)-OH enables the incorporation of arginine residues without unwanted side reactions, making it an indispensable building block for both research and commercial peptide manufacturing.

Product Parameters

Why Cosperpharm?

When your peptide synthesis workflow demands reliable arginine building blocks, Cosperpharm delivers Fmoc-Arg(Pmc)-OH with the quality, documentation, and supply flexibility that research and manufacturing customers require.

Proven performance in Fmoc SPPS. Fmoc-Arg(Pmc)-OH is one of the most widely used arginine derivatives for Fmoc solid-phase peptide synthesis. The Pmc group offers excellent acid lability—removed by TFA in just 1–3 hours—enabling efficient global deprotection. Our rigorous quality control ensures that every batch delivers consistent coupling performance.

Documentation that supports your research and QC. Every shipment includes a Certificate of Analysis (COA) with batch-specific HPLC purity (≥98%), TLC purity (≥98%), acidimetric assay (≥85%), and identity confirmation. Custom quality documentation is available upon request.

Flexible supply across all scales. Cosperpharm supplies Fmoc-Arg(Pmc)-OH from gram-scale research quantities to kilogram-scale batches for commercial peptide manufacturing. R&D samples ship within 5–7 business days; bulk orders are available with transparent lead times.

Technical support from peptide chemistry specialists. Our team has deep expertise in Fmoc SPPS, including the optimization of coupling conditions for arginine derivatives, troubleshooting of side reactions, and scale-up of peptide synthesis. We are here to support your success.

Global reach with competitive pricing. Cosperpharm ships to pharmaceutical companies, CROs, and research institutions worldwide, with full customs documentation included. Volume discounts apply at larger scales, and we communicate all costs upfront.

Safety Information Summary

Product Quality Assurance

Cosperpharm has established a comprehensive quality assurance system for Fmoc-Arg(Pmc)-OH that meets the rigorous expectations of peptide synthesis and pharmaceutical manufacturing:

Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: HPLC purity (≥98%), TLC purity (≥98%), acidimetric assay (≥85%), optical rotation confirmation (−2° ± 2° in DMF), identity confirmation, and appearance inspection (white crystalline powder). Melting point verification is conducted in accordance with established specifications.

Full batch traceability with retention samples. From raw material procurement through protection reactions, purification, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with sufficient retention samples maintained in accordance with Cosperpharm quality procedures.

Stability monitoring program. Cosperpharm conducts ongoing stability studies under recommended storage conditions. Stability summaries are available to support customer quality requirements.

Documentation ready for research and QC use. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, a Material Safety Data Sheet (SDS), and customs documentation for international delivery. Custom quality agreements and additional documentation are available upon request.

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm's manufacturing, quality control, and documentation facilities. Please contact our regulatory team to schedule an audit.

Contact Us

Securing Fmoc-Arg(Pmc)-OH for your peptide synthesis campaign, drug discovery program, or research project should be straightforward. Cosperpharm makes it simple. Reach out to our team today to discuss your requirements, request a quote, or inquire about bulk pricing.