Fmoc-Hser(Trt)-OH

Fmoc-Hser(Trt)-OH is widely recognized as a foundational building block for Fmoc SPPS, particularly valued for its ability to enable selective side-chain modification of homoserine residues. The trityl group in Fmoc-Hser(Trt)-OH can be selectively removed with 1% TFA in DCM containing 5% TIS, allowing the side-chain hydroxyl to be modified while the peptide chain remains anchored to the resin. Additionally, Fmoc-Hser(Trt)-OH has been successfully employed in the preparation of oligonucleotide conjugates, demonstrating its versatility beyond conventional peptide synthesis. For researchers working with homoserine-containing peptides or seeking to incorporate selectively modifiable hydroxyl side-chains into their synthetic targets, Fmoc-Hser(Trt)-OH offers a reliable, well-characterized solution supported by extensive literature precedent.

Product Parameters

Why Cosperpharm?

For medicinal chemists and peptide synthesis laboratories requiring consistent, high-purity Fmoc-protected amino acids, Cosperpharm delivers Fmoc-Hser(Trt)-OH with the quality documentation and supply flexibility that your critical research demands.

High-purity material for reproducible synthesis. Our Fmoc-Hser(Trt)-OH undergoes rigorous analytical release testing including HPLC purity verification (≥98.0%), chiral HPLC for enantiomeric purity confirmation (≥99.8%), optical rotation verification, and identity confirmation via 1H NMR or mass spectrometry. Batch-to-batch consistency ensures your synthesis outcomes remain reproducible across campaigns.

Documentation that supports your regulatory filing. Every shipment includes a Certificate of Analysis with batch-specific purity and characterization data—structured for direct insertion into your method validation or regulatory submission package. Custom quality agreements are available upon request for clients with specific documentation requirements.

Flexible supply across all development phases. Cosperpharm supplies Fmoc-Hser(Trt)-OH in research quantities (1g–50g) for early-stage discovery and process development, as well as larger scale quantities (100g–1kg+) for pilot production and commercial manufacturing. R&D samples ship within 5–7 business days; bulk orders are delivered within 2–3 weeks.

Technical support for complex peptide synthesis. Our process chemistry team can advise on Trt group removal conditions, compatibility with various resin systems, and analytical methods for monitoring coupling efficiency and side-chain modifications—because we have worked extensively with this Fmoc-protected homoserine derivative.

Global reach with transparent pricing. Cosperpharm ships to pharmaceutical manufacturers, CROs, and research institutions worldwide. Volume discounts apply at larger scales, and we communicate lead times upfront—no hidden fees, no unexpected delays.

Storage Conditions

Store Fmoc-Hser(Trt)-OH in a tightly sealed container under inert atmosphere (nitrogen or argon) at 2–8 °C (refrigerated) for short-term storage or at –20 °C for long-term storage. Keep the container dry, protected from light, and stored in a clean, well-ventilated area away from strong oxidizing agents, strong bases, and sources of ignition. The compound is stable under recommended storage conditions and should be opened only in a low-humidity environment to prevent moisture uptake.

Shelf life: 24 months when stored at 2–8 °C in a sealed container under inert atmosphere. Extended shelf life (up to 36 months) is achievable with storage at –20 °C. Accelerated stability data is available upon request.

Handling precautions: Use in a fume hood. Wear chemical-resistant gloves (tested against EN 374 or equivalent), safety goggles, and a lab coat. Avoid generating dust or aerosols. Do not eat, drink, or smoke in work areas. After handling, wash hands thoroughly.

Application Scenarios

Fmoc Solid-Phase Peptide Synthesis (SPPS)

As a building block for automated and manual Fmoc SPPS, Fmoc-Hser(Trt)-OH enables the incorporation of homoserine residues into synthetic peptides. The orthogonal protection strategy allows selective side-chain modification while the peptide remains anchored to the solid support.

Selective Side-Chain Modification

The Trt protecting group in Fmoc-Hser(Trt)-OH can be selectively removed under mild acidic conditions (1% TFA/DCM + 5% TIS), exposing a free hydroxyl group for subsequent functionalization—enabling the synthesis of peptides with tailored side-chain modifications, including phosphorylation, glycosylation, and PEGylation.

Peptide–Oligonucleotide Conjugate Synthesis

Fmoc-Hser(Trt)-OH has been successfully employed to prepare oligonucleotide conjugates, demonstrating its utility in the synthesis of therapeutic peptide–nucleic acid constructs for antisense, siRNA delivery, and diagnostic applications.

Glycopeptide and Phosphopeptide Synthesis

The homoserine side-chain after Trt deprotection provides a free hydroxyl that can be functionalized with carbohydrate or phosphate groups, enabling the synthesis of structurally defined glycopeptides and phosphopeptides for studying protein glycosylation, signal transduction, and disease mechanisms.

Process Development and Scale-Up

Pharmaceutical process chemists use Fmoc-Hser(Trt)-OH for reaction optimization (Fmoc deprotection conditions, Trt removal parameters), impurity mapping, and development of scalable manufacturing routes for peptide-based therapeutics. Cosperpharm provides characterization data and process support for seamless scale-up from laboratory to pilot plant.

Research in Chemical Biology

Fmoc-Hser(Trt)-OH plays a role in studying protein–protein interactions, enzyme mechanisms, and post-translational modifications, contributing to advancements in understanding complex biological systems and the development of novel therapeutic strategies.

Contact Us

Ready to secure Fmoc-Hser(Trt)-OH for your peptide synthesis project? Contact Cosperpharm today—our team is standing by to provide quotes, answer technical questions, and discuss custom supply arrangements tailored to your specific requirements.