Fmoc-Orn(Trt)-OH

Fmoc-Orn(Trt)-OH is a cornerstone building block in Fmoc/tBu solid-phase peptide synthesis, enabling the incorporation of ornithine — an important amino acid involved in urea cycle metabolism and polyamine biosynthesis — into synthetic peptide sequences. The Fmoc group on the α-amino position allows for facile, mild deprotection with piperidine, while the trityl group on the δ-amino side chain provides acid-labile protection that is selectively removed during final cleavage from the resin. Fmoc-Orn(Trt)-OH is widely utilized in the synthesis of side-chain to side-chain cyclic peptides, branched peptides, and peptide conjugates for pharmaceutical research and drug development. As an orthogonally protected ornithine derivative, Fmoc-Orn(Trt)-OH serves as an essential reagent for researchers developing peptide-based therapeutics, antimicrobial peptides, and cell-penetrating peptides. The high chiral purity of Fmoc-Orn(Trt)-OH (≥99.9% enantiomeric excess by chiral HPLC) ensures that the stereochemical integrity of the L-ornithine scaffold is preserved throughout peptide assembly.

Product Parameters

Why Cosperpharm?

Chiral purity is non-negotiable in peptide therapeutics. Any racemization or impurity in your Fmoc-amino acid building block will propagate through the entire peptide sequence and compromise biological activity. Our analytical release protocol for Fmoc-Orn(Trt)-OH includes chiral HPLC verification (≥99.9% ee), HPLC purity, water content (Karl Fischer), optical rotation, and identity confirmation by ¹H NMR and mass spectrometry — because the success of your SPPS campaign depends on the quality of every building block.

Documentation that supports regulatory submission. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, a Material Safety Data Sheet (SDS), and customs documentation for international delivery. Custom quality agreements and stability summaries are available upon request.

Flexible supply across all development stages. Cosperpharm supplies Fmoc-Orn(Trt)-OH across the full range of applications — from gram-scale quantities for research and method development to kilogram-scale batches for process validation and commercial peptide manufacturing. R&D samples ship within 5–7 business days; bulk orders ship within 2–3 weeks.

Technical support for the full peptide synthesis workflow. Our process chemistry team can advise on coupling conditions, deprotection strategies, and troubleshooting for challenging sequences involving ornithine residues — because we have worked extensively with this orthogonally protected amino acid across multiple peptide manufacturing campaigns.

Global reach with transparent pricing. Cosperpharm ships to pharmaceutical manufacturers, CROs, and analytical laboratories worldwide, with full customs documentation included. Volume discounts apply at larger scales, and we communicate lead times upfront — no hidden fees, no unexpected delays.

Product Advantages

 Orthogonal Protection for Selective Deprotection

Fmoc-Orn(Trt)-OH features a base-labile Fmoc group on the α-amino position and an acid-labile trityl (Trt) group on the δ-amino side chain. This orthogonal protection strategy enables selective deprotection at different stages of SPPS — the Fmoc group is removed with piperidine during chain elongation, while the Trt group is cleaved during final TFA-mediated resin cleavage. This allows ornithine residues to be incorporated into peptide sequences without premature side chain reactions.

 High Chiral Purity Preserves Stereochemical Integrity

Fmoc-Orn(Trt)-OH is available with ≥99.9% enantiomeric excess by chiral HPLC, ensuring that the L-configuration of the ornithine scaffold is maintained throughout peptide synthesis. The D-enantiomer content is rigorously controlled at ≤0.1% — critical for peptide therapeutics where stereochemistry directly impacts receptor binding and biological activity.

 Versatile Building Block for Complex Peptides

Fmoc-Orn(Trt)-OH serves as a key building block for the synthesis of side-chain to side-chain cyclic peptides, branched peptides, and peptide conjugates. The δ-amino group, after Trt deprotection, provides a handle for further functionalization — including cyclization, PEGylation, conjugation to targeting ligands, or attachment of fluorophores for imaging applications.

 High Purity Grades for Every Application

Cosperpharm supplies Fmoc-Orn(Trt)-OH at multiple quality levels: standard grade (≥95% HPLC) for routine peptide synthesis and process development; and high-purity grade (≥99% to ≥99.9% chiral HPLC) for GMP peptide manufacturing, regulated pharmaceutical applications, and quality control reference standards.

 Broad Utility in Peptide Drug Discovery

Fmoc-Orn(Trt)-OH is essential for the synthesis of antimicrobial peptides, cell-penetrating peptides, cyclic peptide therapeutics, and peptide-drug conjugates. Ornithine-containing peptides have been extensively studied for applications ranging from oncology to infectious disease to metabolic disorders.

FAQ

Q1: What is Fmoc-Orn(Trt)-OH?

A: Fmoc-Orn(Trt)-OH (Nα-Fmoc-Nδ-trityl-L-ornithine, CAS 1998701-26-0) is an orthogonally protected derivative of the amino acid L-ornithine. The α-amino group is protected by the base-labile Fmoc group, and the δ-amino side chain is protected by the acid-labile trityl (Trt) group.

Q2: What is the difference between Fmoc-Orn(Trt)-OH and free L-ornithine?

A: Fmoc-Orn(Trt)-OH is the protected form of L-ornithine. The free amino acid has two unprotected amino groups that would participate in unwanted side reactions during peptide synthesis. The Fmoc and Trt protecting groups in Fmoc-Orn(Trt)-OH selectively block these reactive sites, allowing controlled incorporation of ornithine into peptide sequences.

Quality Assurance at Cosperpharm

Each batch undergoes:

 Gas chromatography (GC) – purity ≥97.0%

 Non‑aqueous titration – purity ≥97.0%

 Refractive index – confirmatory analysis

 ¹H NMR – structural verification

 Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

Contact Us

Need Fmoc-Orn(Trt)-OH for your peptide synthesis campaign or drug discovery program? Cosperpharm makes it simple to source this essential building block with the quality and documentation you require. Reach out to our team today — we're ready to support your project from research to production.