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Fmoc-D-Tyr(Et)-OH (N‑[(9H‑fluoren‑9‑ylmethoxy)carbonyl]‑O‑ethyl‑D‑tyrosine; C26H25NO5; MW 431.49 g/mol) is an N‑α‑Fmoc protected, O‑ethylated derivative of the non‑natural D‑tyrosine amino acid. The molecular architecture comprises a fluorenylmethoxycarbonyl carbamate protecting the α‑amino group, a free carboxylic acid terminus for amide bond formation, and a p‑ethoxybenzyl side chain where the phenolic –OH of tyrosine has been alkylated to the ethyl ether (–OEt).

Fmoc-Val-OH (N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valine; C20H21NO4; MW 339.39 g/mol) is an N‑α‑Fmoc protected derivative of the branched‑chain amino acid L‑valine. The molecular structure comprises a fluorenylmethoxycarbonyl carbamate attached to the α‑amino group of L‑valine, with a free carboxylic acid terminus available for amide bond formation.

Fmoc-Leu-OH (N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-leucine; C21H23NO4; MW 353.42 g/mol) is an N‑α‑Fmoc (fluorenylmethyloxycarbonyl) protected derivative of the essential branched‑chain amino acid L‑leucine. The molecular architecture consists of a fluorenylmethoxycarbonyl carbamate linked to the α‑amino group of L‑leucine, while the carboxylic acid terminus remains free for subsequent amide bond formation.

Fmoc-Glu-OAll (N-α-Fmoc-L-glutamic acid α-allyl ester, IUPAC: (4S)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-5-oxo-5-prop-2-enoxypentanoic acid) is an orthogonally protected glutamic acid derivative that carries a base‑labile Fmoc group at the α‑amino terminus and an allyl ester (OAll) protecting the α‑carboxyl group, while the side‑chain γ‑carboxyl remains a free carboxylic acid.

Fmoc-Asp(OAll)-OH (N-α-Fmoc-L-aspartic acid α-allyl ester, IUPAC: (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxo-4-prop-2-enoxybutanoic acid) is an orthogonally protected aspartic acid derivative featuring two distinct protection strategies: a base-labile Fmoc (9-fluorenylmethoxycarbonyl) group protecting the α-amino terminus, and an allyl ester (OAll) protecting the α-carboxyl group.

Fmoc-D-Ser(tBu)-OH (N-[(9H-fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-D-serine) is an N-Fmoc protected, O-tert-butyl protected derivative of the non‑natural amino acid D‑serine. The structure comprises a 9‑fluorenylmethyloxycarbonyl (Fmoc) group attached to the α‑amino group, and an acid‑labile tert‑butyl ether (tBu) group protecting the side‑chain hydroxyl. This orthogonal protection scheme—base‑labile Fmoc on the amine, acid‑labile tBu on the side‑chain—is fundamental to its role in Fmoc solid‑phase peptide synthesis (SPPS).