Pyridine, 2,6-dichloro-4-(1,1-dimethylethyl)- is an enabling intermediate for pharmaceutical and agrochemical programs that demand differentiated substitution at the 2‑ and 6‑positions of a pyridine ring. The reactivity differential of the two chlorine atoms in Pyridine, 2,6-dichloro-4-(1,1-dimethylethyl)- can be exploited through catalyst‑controlled cross‑coupling or careful temperature manipulation to achieve mono‑substitution with high selectivity. Once the first chlorine is displaced, Pyridine, 2,6-dichloro-4-(1,1-dimethylethyl)- becomes an excellent building block for assembling orthogonally decorated pyridines, a motif common in kinase hinge binders, herbicides, and antiviral agents. Process groups appreciate that Pyridine, 2,6-dichloro-4-(1,1-dimethylethyl)- is a stable, easy‑to‑handle liquid or low‑melting solid that can be stored and dispensed without special equipment.
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Parameter |
Specification |
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Product Name |
Pyridine, 2,6-dichloro-4-(1,1-dimethylethyl)- |
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CAS Number |
1350449-23-8 |
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Molecular Formula |
C₉H₁₁Cl₂N |
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Molecular Weight |
204.10 g/mol |
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Appearance |
Colorless to pale yellow liquid or low-melting solid |
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Boiling Point |
~95–100°C / 10 mmHg (typical) |
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Purity (GC/HPLC) |
≥98.0% |
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Solubility |
Freely soluble in common organic solvents; insoluble in water |
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Storage Condition |
Room temperature or 2–8°C, sealed, protected from moisture |
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Shelf Life |
24 months under recommended conditions |
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Advantage |
Detail |
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Production Strength |
GMP-certified campus spanning 100+ mu, 3 multi-purpose workshops, 6 D-grade clean zone production lines, and 150+ reactors (20L–5000L), supporting high/low temp, anaerobic & hydrogenation; kg to ton scale production. |
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Fast Delivery |
R&D samples: one week; commercial orders: 1–2 months after payment. Express (DHL/FedEx) or air/sea freight available. |
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Global Partners |
Trusted by 30+ pharmaceutical companies in USA, Europe, India, Brazil, and Southeast Asia; long-term cooperation with generic drug manufacturers, CROs, and impurity standard distributors. |
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Licensed Exporter |
Valid drug import/export license — no compliance delays. |
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Dual Quality Grades |
Both research/pharma grade（≥98%）and high-purity impurity grade（≥99%）available to meet diverse customer needs. |
Q1: What storage condition do you recommend for bulk quantities?
A: Keep the container tightly sealed in a cool, dry area. For drums, a nitrogen blanket is advised if the product will be dispensed repeatedly.
Q2: Is the tert‑butyl group stable under acidic or basic conditions?
A: The tert‑butyl group is stable under most standard cross‑coupling conditions (base, heat). Strong acids at elevated temperatures may cause dealkylation, so we recommend avoiding prolonged treatment with superacids.
Each batch undergoes:
● Gas chromatography (GC) – purity ≥97.0%
● Non‑aqueous titration – purity ≥97.0%
● Refractive index – confirmatory analysis
● ¹H NMR – structural verification
● Appearance – colorless to light yellow to light orange clear liquid
A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.
Whether you need a sample for feasibility or a full production schedule for a late‑stage intermediate, Cosperpharm is ready to support. Connect with our commercial team to discuss stock availability and volume pricing.
Address
No. 2 Yangguang 3rd Road, Duodao Chemical Cycle Industrial Park, Jingmen City, Hubei Province, China
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