β-Nicotinamide

β-Nicotinamide Mononucleotide (β-NMN) is a natural nucleotide and a key intermediate in the synthesis of NAD⁺, an essential coenzyme involved in cellular metabolism and energy production. β-Nicotinamide Mononucleotide is used to study binding motifs within RNA aptamers and ribozyme activation processes. As a research compound, β-Nicotinamide Mononucleotide has gained significant attention due to its potential anti-aging properties. β-Nicotinamide Mononucleotide is also known as fosribnicotinamide and is a key molecule in NAD⁺ biosynthesis. In research contexts, β-Nicotinamide Mononucleotide is used as a reference standard and research tool for studying cellular metabolism and aging.

Product Parameters

Source

Application

Nicotinamide mononucleotide is converted into nicotinamide adenine dinucleotide (NAD), a substance essential for energy metabolism in the body. In mouse studies, it has been demonstrated that nicotinamide mononucleotide activates a gene known as acetyltransferase, thereby exerting effects such as longevity enhancement and diabetes treatment. NAD is a compound naturally produced by the human body, and research has shown that its levels decline with advancing age.

Benefits

(1) Alleviate and improve ischemic damage to cardiac and cerebral tissues

Studies have demonstrated that supplementation with exogenous β-NMN increases NAD+ and NADH levels in the heart, mimics the protective effects of ischemia-reperfusion injury (IPC), enhances deacetylase activity, reduces infarct size, and achieves cardioprotective effects. When cerebral blood circulation becomes abnormal, it can trigger acute cerebrovascular disease, for which β-NMN exhibits ameliorative effects.

(2) Improve oxidative-related degenerative diseases and physical dysfunction

Studies demonstrate that β-NMN can more directly and effectively elevate NAD+ levels, promote the activation of the longevity factor Sirt1, thereby reducing cellular damage and maintaining collagen integrity. This mechanism prevents skin conditions such as dryness, atrophy, sagging, laxity, and fine lines, ultimately delaying skin aging. Cardiovascular diseases primarily arise from irregular relaxation and contraction of myocardial cells; thus, treatment requires restoring and enhancing mitochondrial energy production in these cells.

(3) Therapeutic effects on metabolic diseases

β-NMN promotes the biosynthesis of NAD+, and Nampt-mediated NAD+ biosynthesis is crucial for cellular function, regulating insulin secretion in pancreatic islet cells and thereby exerting hypoglycemic effects.

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