(S)-(-)-Verapamilic Acid Phenethylamine Salt

(S)-(-)-Verapamilic Acid Phenethylamine Salt is the crystalline salt formed between (S)-(-)-Verapamilic Acid and (R)-α-methylbenzylamine, serving as a key intermediate in the chiral resolution process for verapamilic acid. The utility of (S)-(-)-Verapamilic Acid Phenethylamine Salt lies in its role as a crystalline diastereomeric salt that enables efficient separation of the (S)-enantiomer from racemic verapamilic acid. Through resolution with α-methylbenzylamine, (S)-(-)-Verapamilic Acid Phenethylamine Salt can be obtained with high diastereomeric purity, providing a scalable route to the single-enantiomer intermediate required for (S)-verapamil production. As a crystalline intermediate, (S)-(-)-Verapamilic Acid Phenethylamine Salt offers advantages in purification, handling, and process control compared to the oil form of the free acid.

 

 Product Parameters

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Parameter	Specification
Product Name	(S)-(-)-Verapamilic Acid Phenethylamine Salt
CAS Number	194854-18-7
Molecular Formula	C₁₆H₂₁NO₄·C₈H₁₁N
Molecular Weight	412.52 g/mol
Physical Form	Crystalline solid

 

Why Cosperpharm?

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When your verapamil manufacturing campaign requires reliable chiral resolution intermediates, Cosperpharm delivers (S)-(-)-Verapamilic Acid Phenethylamine Salt with the quality and consistency that pharmaceutical manufacturers demand.

 

Resolution efficiency begins here. The diastereomeric salt crystallization of (S)-(-)-Verapamilic Acid Phenethylamine Salt is the key step in producing enantiopure verapamilic acid. Any impurity in this salt will compromise the enantiomeric excess of the final API. Our analytical release protocol ensures high diastereomeric purity — because your resolution yield and final API stereochemistry depend on the quality of this intermediate.

 

Documentation that supports regulatory submission. Every shipment includes a Certificate of Analysis (COA) with batch‑specific HPLC purity, chromatographic traceability, and identity confirmation.

 

Flexible supply for all development stages. Cosperpharm supplies (S)-(-)-Verapamilic Acid Phenethylamine Salt from gram-scale R&D quantities to kilogram-scale batches for commercial manufacturing.

 

Technical support for the resolution process. Our process chemistry team can advise on crystallization conditions, diastereomeric salt purification, and conversion to the free acid — because we understand the intricacies of chiral resolution.

 

Product Advantages

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 Enables Efficient Chiral Resolution

(S)-(-)-Verapamilic Acid Phenethylamine Salt is a key crystalline intermediate in the resolution of racemic verapamilic acid using (R)-α-methylbenzylamine. The diastereomeric salt approach provides a scalable, industrially viable route to single-enantiomer verapamil intermediates.

 

 Crystalline Form for Easy Handling

Unlike the free acid, which is an oil, (S)-(-)-Verapamilic Acid Phenethylamine Salt is a crystalline solid. This crystalline form facilitates purification by recrystallization, improves handling and weighing accuracy, and enhances long‑term storage stability.

 

 High Diastereomeric Purity

(S)-(-)-Verapamilic Acid Phenethylamine Salt can be obtained with high diastereomeric purity (>99% HPLC), ensuring efficient conversion to enantiopure (S)-verapamilic acid.

 

 Direct Precursor to (S)-Verapamil

As the crystalline salt form of the key chiral intermediate, (S)-(-)-Verapamilic Acid Phenethylamine Salt occupies a strategic position in the synthesis of single-enantiomer verapamil.

 

Product Quality Assurance

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Cosperpharm has established a comprehensive quality assurance system for (S)-(-)-Verapamilic Acid Phenethylamine Salt:

 

Thorough analytical characterization. Each batch undergoes HPLC purity verification (≥99%), identity confirmation, and diastereomeric purity analysis where applicable.

 

Full batch traceability. From raw material procurement through synthesis and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number.

 

Documentation ready for regulatory submission. Every shipment includes a Certificate of Analysis (COA) and a Material Safety Data Sheet (SDS).

 

Contact Us

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For reliable supply of (S)-(-)-Verapamilic Acid Phenethylamine Salt and expert support for your chiral resolution process, contact Cosperpharm today. Our team is ready to assist with your intermediate sourcing needs.