3-[2-Chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid

3-[2-Chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid is a next‑generation spiro‑acid building block designed to populate the under‑explored chemical space between classic phenylacetic acids and fully saturated spiro motifs. The acetic acid handle of 3-[2-Chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid can be directly employed as a carboxylate pharmacophore or readily converted into amides, esters, and hydroxamic acids, making the compound a versatile late‑stage intermediate for parallel library synthesis. In drug discovery programmes targeting G‑protein coupled receptors and ion channels, 3-[2-Chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid has demonstrated value as a rigid scaffold that correctly pre‑positions the acid group relative to the halogen‑substituted aromatic ring, helping to improve selectivity profiles. Because 3-[2-Chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid is a fully synthetic entity with a scalable supply chain, it supports everything from milligram‑scale screening to multi‑kilogram preclinical development under consistent quality control.

Product Parameters

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FAQ

Q1: Does this compound contain any stereocenters?

A: No. The spiro‑piperidine ring and the cyclohexane‑acetic acid fragment are both symmetric; the molecule is achiral and obtained as a single entity.

Q2: How should I dissolve it for biological assays?

A: Prepare a concentrated stock solution in DMSO (10–50 mM) and dilute into assay buffer. The free acid is slightly soluble in water at neutral pH but becomes more soluble as the pH rises above its pKa (~4.6). Ensure the final DMSO concentration does not exceed 1% in cellular assays.

Quality Assurance at Cosperpharm

Each batch undergoes:

● Gas chromatography (GC) – purity ≥97.0%

● Non‑aqueous titration – purity ≥97.0%

● Refractive index – confirmatory analysis

● ¹H NMR – structural verification

● Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

Contact Us

Looking for a spiro‑acid that brings both rigidity and the right halogen pattern to your binding pocket? Contact Cosperpharm today to discuss your requirements for 3-[2-Chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid. From initial profiling quantities to full‑scale campaign batches, we are ready to provide the quality, documentation, and technical insight that your project needs. Let’s talk about how we can help you move from concept to candidate—fast and reliably.