Lanthanum Carbonate is an inorganic phosphate-binding compound consisting of lanthanum(III) cations and carbonate anions, typically existing as the octahydrate salt. The molecule of Lanthanum Carbonate functions as a non-calcium, non-aluminium phosphate binder that dissociates in the acidic environment of the upper gastrointestinal tract, releasing lanthanum ions that bind dietary phosphate to form insoluble lanthanum phosphate complexes.
Pazopanib Hydrochloride is a potent, multi-targeted receptor tyrosine kinase inhibitor, formulated as the hydrochloride salt to enhance pharmaceutical properties. Structurally, Pazopanib Hydrochloride consists of a pyrimidine-2,4-diamine core with a 2,3-dimethyl-2H-indazol-6-yl substituent via a methylamino linker, and a 2-methylbenzenesulfonamide group at the 5-position.
Ticagrelor is the first reversibly binding oral P2Y₁₂ platelet receptor antagonist, featuring a complex cyclopentane-triazolopyrimidine structure with multiple stereocentres. Structurally, Ticagrelor consists of a triazolo[4,5-d]pyrimidine core with a propylthio substituent at the 5-position, a cyclopropylamino group at the 7-position, and a cyclopentane ring bearing three hydroxyl groups and a hydroxyethoxy substituent.
Regorafenib Monohydrate is an oral multi-kinase inhibitor that targets angiogenic, stromal, and oncogenic receptor tyrosine kinases. Structurally, Regorafenib Monohydrate consists of a 4-phenoxy-N-methylpicolinamide core with a urea linkage connecting to a 4-chloro-3-(trifluoromethyl)phenyl group, and a fluorine substituent on the central phenyl ring.
Raltitrexed is a potent and specific thymidylate synthase (TS) inhibitor, belonging to the quinazoline folate analogue class of antineoplastic agents. Structurally, Raltitrexed consists of a 2-methyl-4-oxo-quinazoline ring system linked via a methyl-methylamino bridge to a thiophene ring, which is further connected to a glutamic acid moiety through a carboxamide linkage.
Aprepitant is a selective high-affinity antagonist of the human substance P/neurokinin 1 (NK₁) receptor, featuring a complex morpholine core with three stereocenters that define its pharmacological activity. The molecule consists of a 1,2,4-triazol-3-one ring linked via a methylene bridge to a 2,3-disubstituted morpholine ring, which carries a 4-fluorophenyl group and a chiral 1-[3,5-bis(trifluoromethyl)phenyl]ethoxy substituent.
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