Lanthanum Carbonate

Lanthanum Carbonate is a phosphate binder indicated for the management of hyperphosphataemia in patients with end-stage renal disease (ESRD). As a non-calcium-containing agent, Lanthanum Carbonate offers an important therapeutic option for dialysis patients who need to control serum phosphate levels without the risk of calcium overload. Lanthanum Carbonate achieves its effect by binding to dietary phosphate in the gastrointestinal tract, forming insoluble complexes that are excreted in the faeces. The drug is administered as a chewable tablet and should be taken with or immediately after meals to maximise phosphate binding. Lanthanum Carbonate and its related impurities serve as critical reference standards for analytical method development and quality control applications.

 Product Parameters

Indication

Hyperphosphatemia. This product is a phosphate binder, indicated for the treatment of hyperphosphatemia in patients with chronic renal failure undergoing hemodialysis or continuous ambulatory peritoneal dialysis (CAPD).

Physicochemical Properties

Lanthanum Carbonate, chemical formula La₂(CO₃)₃·8H₂O. Molecular weight 601.97. White crystal. Relative density 2.6-2.7. Insoluble in water and acetone, soluble in dilute acids, slightly soluble in CO₂ aqueous solution. Soluble in alkali metal carbonates, and double salts such as K[La(CO₃)₂]·6H₂O can be crystallized after dilution, per. Releases CO₂ when heated. When heated, it first forms basic carbonate, and then generates oxide upon ignition. Lanthanum carbonate has high phosphorus-binding capacity, can exert a good phosphorus-lowering effect throughout the digestive tract, with mild adverse reactions, high cost-effectiveness and good clinical compliance, and is a relatively ideal phosphate binder to date.

Usage and dosage

Lanthanum Carbonate is an oral medication. It must be chewed before swallowing, and do not swallow the tablet whole. The tablet may be crushed to facilitate chewing. This product should be taken with food or immediately after a meal. The dose for each administration is the daily dose divided by the number of meals. Patients should follow the recommended diet on  to control phosphorus and fluid intake. This product is a chewable tablet, which can avoid excessive fluid intake. When using this product, serum phosphorus should be monitored, and the dosage should be gradually adjusted every 2 to 3 weeks until serum phosphorus reaches an acceptable level, after which serum phosphorus should be monitored regularly.

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