Boc-L-2-aminobutyric acid

Boc-L-2-aminobutyric acid is a protected chiral building block widely utilized in Boc solid-phase peptide synthesis (Boc SPPS) for introducing L-2-aminobutyric acid residues into peptides and pharmaceutical intermediates. The Boc group in Boc-L-2-aminobutyric acid serves as a protecting group for the amino functionality during peptide synthesis, allowing for selective modification of amino acids without interference from other functional groups. As a pharmaceutical intermediate, Boc-L-2-aminobutyric acid is employed in the manufacturing of various pharmaceutical compounds. The chiral L-configuration of Boc-L-2-aminobutyric acid is essential for maintaining biological activity in peptide-based therapeutics, making it a critical building block in drug discovery and development programs. The compound‘s stability and crystalline nature make Boc-L-2-aminobutyric acid convenient to handle and store for long-term research and manufacturing campaigns.

 

Product Parameters

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Parameter	Specification
Product Name	Boc-L-2-aminobutyric acid
CAS Number	34306-42-8
Molecular Formula	C₉H₁₇NO₄
Molecular Weight	203.24 g/mol
Appearance	White to off-white solid
Melting Point	70–74 °C
Boiling Point	334.5±25.0℃
Optical Rotation	[α]²⁰/D −18.5±2° (c = 1% in methanol)
Solubility	Slightly soluble in water
Flash Point	113 °C
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
pKa	4.00±0.10
Density	1.101±0.06 g/cm3

Synthetic Route

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Boc-L-2-aminobutyric acid is typically synthesized from DL-2-aminobutyric acid via the following procedure: dissolve 10.3 g of DL-2-aminobutyric acid in a mixture of 95 mL of 1 M NaOH solution and 65 mL of methanol; add 27.5 mL of diisopropyl carbonate (i.e., Boc anhydride, see Equation 1 in Chemical Book 2) under ice bath heating, then gradually升温 to room temperature while stirring for 12 hours. After reaction completion, remove methanol by rotary evaporation, adjust pH to 1–2 with 1 M hydrochloric acid, extract three times with 50 mL of ethyl acetate each, wash twice with saturated saline solution (40 mL each), dehydrate with anhydrous sulfuric acid, and finally obtain 18.9 g of colorless solid (93.4%).

Application

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(1) Synthesis of the antitumor drug idelalisib   

(2) Synthesis of the antitumor drug edelizib  

(3) Synthesis of the intermediate compound of o-fluoro-o-iminobenzoic acid

 

Product Quality Assurance

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Cosperpharm has established a comprehensive quality assurance system for Boc-L-2-aminobutyric acid that meets the rigorous expectations of pharmaceutical intermediate and research-grade applications:

 

Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: HPLC purity (≥98%), optical rotation verification ([α]²⁰/D −18.5±2°, c = 1% in methanol), melting point verification (70–79 °C), and appearance inspection (white to off-white powder).

 

Full batch traceability. From raw material procurement through Boc protection, purification, crystallization, drying, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with retention samples maintained in accordance with Cosperpharm quality procedures.

 

Documentation ready for regulatory submission. As a pharmaceutical intermediate, Boc-L-2-aminobutyric acid is used in drug substance manufacturing and requires comprehensive documentation. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, a Material Safety Data Sheet (SDS), and customs documentation. DMF-ready documentation, stability summaries, and custom quality agreements are available upon request.

 

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm‘s manufacturing, quality control, and documentation facilities. Please contact our regulatory team to schedule an audit.

 

 Contact Us

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Interested in sourcing Boc-L-2-aminobutyric acid for your next peptide synthesis campaign or pharmaceutical manufacturing project? Cosperpharm is here to help. Reach out to our team for pricing, documentation, or technical support — we look forward to supporting your success.