Melitracen HCL

Melitracen Hydrochloride is a tricyclic antidepressant with a distinct anthracene-based scaffold and dopamine receptor antagonist activity. As a hydrochloride salt, Melitracen Hydrochloride offers improved aqueous solubility and stability, making it suitable for pharmaceutical formulation and research applications. The mechanism of Melitracen Hydrochloride involves potential antagonism of dopamine D1 and D2 receptors, which may contribute to its antidepressant and analgesic effects. In clinical practice, Melitracen Hydrochloride is often combined with the antipsychotic flupenthixol for the treatment of trigeminal neuralgia, anxiety, and depression, leveraging the complementary pharmacological profiles of both agents. The unique pharmacological profile of Melitracen Hydrochloride makes it a valuable tool for studying dopamine receptor-mediated mechanisms in neuropsychiatric and pain research.

Product Parameters

Bioactivity

Melitracen hydrochloride (Thymeol) is a potential dopamine D1/2 receptor antagonist with antidepressant effects.

In vivo studies

A single oral administration of imipramine or melitracen leads to significant and persistent mydriasis in mice. The mydriatic effect of melitrazine is more pronounced and longer-lasting. Melitrazine is more effective in terms of behavioral excitation. A single oral dose of melitracen reduces catecholamine levels in the brain stem, cerebral cortex, spleen, and adrenal glands. In rats that received daily administration of melitracene for 13 and 15 weeks, there were no significant changes in catecholamine levels in the brain stem, cerebral cortex, and spleen. However, epinephrine levels decreased slightly.

Product Advantages

 Unique Anthracene-Based Scaffold

Melitracen Hydrochloride features a distinct anthracene-derived tricyclic structure with a dimethylated central ring, differentiating it from other TCAs such as amitriptyline and imipramine.

 Dopamine Receptor Antagonist Activity

Melitracen Hydrochloride acts as a potential dopamine D1/D2 receptor antagonist, offering a unique mechanism for studying dopamine-mediated neuropsychiatric and pain pathways.

 Clinically Validated Combination Therapy

Melitracen Hydrochloride is co-administered with flupenthixol for the treatment of trigeminal neuralgia, anxiety, and depression, supporting its clinical utility in pain and mood disorders.

 High Purity for Research

Melitracen Hydrochloride is available with >98% HPLC purity and comprehensive characterization, ensuring reliable and reproducible results.

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