Products

Filgotinib (GLPG0634, CAS 1206161-97-8) is an orally bioavailable, selective inhibitor of Janus kinase 1 (JAK1), a member of the JAK family of intracellular tyrosine kinases that plays a central role in the JAK/STAT (signal transducer and activator of transcription) signaling pathway.

Filgotinib Maleate (CAS 1802998-75-9) is the maleate salt form of filgotinib, an orally bioavailable, selective Janus kinase 1 (JAK1) inhibitor. Structurally, Filgotinib Maleate consists of the filgotinib free base (C₂₁H₂₃N₅O₃S) in a 1:1 stoichiometric ratio with maleic acid (C₄H₄O₄), giving a molecular formula of C₂₅H₂₇N₅O₇S and a molecular weight of 541.58 g/mol . The maleate salt form enhances the aqueous solubility and long-term crystallinity of the API compared to the free base, facilitating pharmaceutical formulation and improving stability during manufacturing and storage .

Tapinarof (CAS 79338-84-4), also known as benvitimod or GSK2894512, is a naturally occurring stilbene compound originally isolated from the bacterium Photorhabdus luminescens . Structurally, Tapinarof features a stilbene core (1,2-diphenylethene) with a molecular formula of C₁₇H₁₈O₂ and a molecular weight of 254.32 g/mol .

Resmetirom (CAS 920509-32-6), also known as MGL-3196 or VIA-3196, is a first-in-class, liver-directed, orally active, selective thyroid hormone receptor β (THR-β) agonist . Structurally, Resmetirom features a complex molecular architecture centered on a pyridazinone core, with a 4-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy substituent linked to a dichlorophenyl ring, which is further connected to a triazine-dione-carbonitrile moiety .

Ozanimod (CAS 1306760-87-1), also known as RPC1063, is a selective, orally bioavailable sphingosine 1-phosphate receptor 1 (S1P₁) modulator . Structurally, Ozanimod features a complex molecular architecture centered on a 1,2,4-oxadiazole core linking an indane-amine moiety to a cyanophenyl isopropoxy group, with a molecular formula of C₂₃H₂₄N₄O₃ and a molecular weight of 404.46 g/mol . The molecule contains a chiral center at the indane 1-position, with the (S)-enantiomer being the active pharmacological form .

Luliconazole (CAS 187164-19-8) is an optically active imidazole antifungal agent featuring a unique dithiolane ring structure conjugated to an imidazole acetonitrile moiety . The molecule contains a chiral center at the 4-position of the 1,3-dithiolane ring, with the active pharmaceutical ingredient existing as the R-enantiomer .