Tipiracil Hydrochloride

Tipiracil Hydrochloride is a critical pharmaceutical ingredient and biochemical research tool that functions as a thymidine phosphorylase inhibitor in the combination therapy TAS-102 (trifluridine/tipiracil, Lonsurf®). As one of the two active components in TAS-102, Tipiracil Hydrochloride increases the bioavailability of trifluridine by blocking the enzyme thymidine phosphorylase, which would otherwise metabolize and degrade trifluridine. Tipiracil Hydrochloride is combined with trifluridine at a molar ratio of 1:0.5 (trifluridine:tipiracil) in the approved drug product. In research contexts, Tipiracil Hydrochloride is extensively used to study thymidine phosphorylase inhibition, nucleoside analog pharmacology, and combination therapy strategies for colorectal cancer and other solid tumors. The compound’s selectivity for TPase over other pyrimidine‑metabolizing enzymes makes Tipiracil Hydrochloride an invaluable tool for investigating the role of thymidine phosphorylase in tumor angiogenesis and drug resistance mechanisms.

 

 Product Parameters

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Parameter	Specification
Product Name	Tipiracil Hydrochloride
CAS Number	183204-72-0
Molecular Formula	C₉H₁₂Cl₂N₄O₂
Molecular Weight	279.12 g/mol
Appearance	White to off-white to beige powder
Melting Point	245°C
Storage Condition	2–8°C

 

Bioactivity

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Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that catalyzes the degradation of trifluoropyridine into trifluorothymidine. Its combination with trifluoropyridine enhances the bioavailability of trifluoropyridine.

 

In Vitro Study

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Tipiracil has antiangiogenic effect, and inhibits proliferation of endothelial cells. Tipiracil is a potent inhibitor of thymidine phosphorylase, which is the enzyme that degrades FTD.

 

Why Cosperpharm?

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When your colorectal cancer drug development program or analytical laboratory requires high‑purity Tipiracil Hydrochloride, Cosperpharm delivers with the quality, documentation, and supply flexibility that pharmaceutical customers demand.

 

Purity that supports combination therapy development. Tipiracil Hydrochloride is a critical component of TAS-102 (Lonsurf®), and any impurity in this starting material can affect the efficacy and safety of the final combination drug product. Our analytical release protocol includes HPLC purity verification (≥98%), water content determination, residual solvent analysis, and identity confirmation — because the quality of your trifluridine/tipiracil combination depends on the purity of this building block.

 

Documentation for regulatory submission. Every reference‑grade shipment of Tipiracil Hydrochloride includes a Certificate of Analysis (COA) with batch‑specific HPLC purity, chromatographic traceability, and residual solvent data — structured for direct insertion into your method validation package. DMF‑ready documentation, stability summaries, and custom quality agreements are available upon request.

 

Flexible supply across all development stages. Cosperpharm supplies Tipiracil Hydrochloride across the full range of applications — from milligram quantities for analytical method development and research use, to gram‑scale batches for process validation and pilot production, to kilogram quantities for commercial manufacturing. R&D samples ship within 5–7 business days; bulk orders ship within 2–3 weeks.

 

Technical support for the full synthetic cascade. Our process chemistry team can advise on the synthesis and purification of Tipiracil Hydrochloride, compatibility with trifluridine in the combination formulation, and analytical methods for detecting process‑related impurities — because we have worked extensively with this thymidine phosphorylase inhibitor across multiple research and manufacturing campaigns.

 

Global reach with transparent pricing. Cosperpharm ships to pharmaceutical manufacturers, CROs, and analytical laboratories worldwide, with full customs documentation included. Volume discounts apply at larger scales, and we communicate lead times upfront — no hidden fees, no unexpected delays.

 

Contact Us

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Looking for Tipiracil Hydrochloride to support your colorectal cancer drug development, analytical method validation, or combination therapy research? Cosperpharm delivers high‑quality material with the documentation you need. Get in touch — we’re ready to assist.