(R)-3-tert-Butoxy-2-aminopropanamide

(R)-3-tert-Butoxy-2-aminopropanamide is a chiral pharmaceutical intermediate and specialized research compound that has gained significant attention in drug discovery and organic synthesis due to its unique combination of functional groups and defined stereochemistry. As a tert-butyl-protected derivative of a chiral amino amide, (R)-3-tert-Butoxy-2-aminopropanamide serves as a key building block in the synthesis of protease inhibitors, peptide mimetics, and other bioactive molecules where stereochemical control is paramount. The compound’s structure — featuring a primary amine, a primary amide, and a tert-butyl ether — provides multiple points for selective functionalization, enabling the construction of diverse chemical libraries for drug discovery campaigns.

 

In peptide chemistry and medicinal chemistry research, (R)-3-tert-Butoxy-2-aminopropanamide is utilized as a chiral synthon for introducing the (R)-configured serine-derived motif into target molecules. The tert-butoxy group enhances the compound’s stability against hydrolysis while conferring moderate lipophilicity that can be tuned through selective deprotection. The primary amide functionality, meanwhile, can participate in hydrogen bonding interactions that are often critical for biological activity, making (R)-3-tert-Butoxy-2-aminopropanamide a valuable scaffold for structure-activity relationship (SAR) studies.

 

For pharmaceutical process chemists and medicinal chemists, (R)-3-tert-Butoxy-2-aminopropanamide offers a well-defined chiral platform that can be elaborated into more complex structures through amide coupling, reductive amination, or functional group transformations. The compound’s established synthetic routes and reliable enantiomeric purity make (R)-3-tert-Butoxy-2-aminopropanamide a trusted intermediate in both academic research and industrial drug development programs.

 

Product Parameters

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Parameter	Specification
Product Name	(R)-3-tert-Butoxy-2-aminopropanamide
CAS Number	211755-73-6
Molecular Formula	C₇H₁₆N₂O₂
Molecular Weight	160.21 g/mol
Density	1.031 g/cm³ (predicted)
Boiling Point	293 °C (predicted)
Flash Point	53 °C

Why Cosperpharm?

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When your peptide synthesis, medicinal chemistry program, or chiral intermediate manufacturing requires a reliable source of enantiopure (R)-3-tert-Butoxy-2-aminopropanamide, Cosperpharm delivers with the quality, documentation, and supply flexibility that research and development teams demand.

 

Enantiopurity is non-negotiable. The (R)-configuration of this amino amide is the defining feature that enables stereospecific downstream chemistry. Any racemization or contamination with the (S)-enantiomer will compromise your biological assay results or final product specifications. Cosperpharm’s (R)-3-tert-Butoxy-2-aminopropanamide is released with chiral HPLC verification to confirm enantiomeric excess, ensuring that the stereochemical integrity you require is preserved from our warehouse to your reaction flask.

 

Documentation that supports your research. Every shipment of (R)-3-tert-Butoxy-2-aminopropanamide includes a Certificate of Analysis (COA) with batch-specific purity data, chromatographic profiles, and identity confirmation. For customers requiring additional regulatory or quality documentation, Cosperpharm provides custom quality agreements, stability summaries, and analytical data packages upon request.

 

Flexible supply across all scales. Cosperpharm supplies (R)-3-tert-Butoxy-2-aminopropanamide across the full range of applications — from milligram quantities for early-stage medicinal chemistry screening and SAR studies, to gram-scale batches for process development and route scouting, to kilogram quantities for preclinical and pilot-scale production. R&D samples ship within 5–7 business days; bulk orders are coordinated based on your production timeline.

 

Technical support from chemists who understand your chemistry. Our process chemistry team can advise on deprotection strategies for the tert-butoxy group, compatibility with common peptide coupling conditions, and analytical methods for monitoring chiral integrity — because we have worked extensively with this class of amino amide intermediates.

 

Global reach with transparent communication. Cosperpharm ships to pharmaceutical companies, CROs, and academic research institutions worldwide, with full customs documentation included. We communicate lead times and availability upfront — no surprises, no hidden fees.

 

Product Advantages

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Defined (R)-Stereochemistry for Enantioselective Synthesis

(R)-3-tert-Butoxy-2-aminopropanamide provides a reliable source of the (R)-configured serine-derived motif, enabling stereospecific incorporation into target molecules without the need for costly chiral resolution or asymmetric induction steps. The defined stereochemistry is essential for medicinal chemistry programs where enantiopurity directly correlates with biological activity and safety.

 

 Dual Functional Groups Enable Diverse Derivatization

The compound features three orthogonal functional handles: a primary amine (for amide coupling, reductive amination, or carbamate formation), a primary amide (for further functionalization or hydrogen bonding interactions), and a tert-butyl ether (which can be selectively deprotected under acidic conditions to reveal a free hydroxyl group). This structural richness enables the construction of diverse chemical libraries from a single chiral intermediate.

 

 Bulky tert-Butoxy Group Modulates Physicochemical Properties

The tert-butoxy group imparts moderate lipophilicity (LogP ≈ 1.01) and enhances stability against hydrolysis, making (R)-3-tert-Butoxy-2-aminopropanamide suitable for a wide range of reaction conditions. The steric bulk of the tert-butyl group can also influence conformational preferences in the final target molecules, potentially improving receptor binding selectivity.

 

 Versatile Building Block for Multiple Therapeutic Areas

(R)-3-tert-Butoxy-2-aminopropanamide serves as a key intermediate in the synthesis of protease inhibitors, peptide mimetics, and other chiral pharmaceuticals. Its unique combination of functional groups makes it a valuable scaffold for drug discovery programs targeting diverse therapeutic areas, including oncology, infectious diseases, and metabolic disorders.

 

 Reliable Synthetic Accessibility with Established Routes

The compound benefits from well-established synthetic routes starting from readily available chiral precursors, ensuring consistent quality and supply. Cosperpharm’s manufacturing processes are validated to deliver (R)-3-tert-Butoxy-2-aminopropanamide with ≥95% purity and reliable enantiomeric excess, batch after batch

 

Quality Assurance at Cosperpharm

Each batch undergoes:

 Gas chromatography (GC) – purity ≥97.0%

 Non‑aqueous titration – purity ≥97.0%

 Refractive index – confirmatory analysis

 ¹H NMR – structural verification

 Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

 

Contact Us

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Finding a trusted source of enantiopure (R)-3-tert-Butoxy-2-aminopropanamide for your synthesis or medicinal chemistry program shouldn't slow you down. Cosperpharm makes it simple to secure the chiral intermediates you need — with the quality documentation to back them up.