2-methylbenzo[d]thiazole-6-carboxylic acid

2-Methylbenzo[d]thiazole-6-carboxylic acid (CAS 6941-28-2) is a versatile heterocyclic building block belonging to the benzothiazole family of pharmacophores. The compound features a methyl group at the 2-position of the thiazole ring and a carboxylic acid group at the 6-position of the fused benzene ring, forming an electron-rich aromatic system that can participate in hydrogen bonding and π-π stacking interactions, which are essential for biological recognition and reactivity.

In agricultural chemistry, 2-methylbenzo[d]thiazole-6-carboxylic acid has been identified as a reagent for synthetic studies on fungicidal agents, playing a role in the development of new compounds to combat plant‑pathogenic fungi, including seed‑ and soil‑borne pathogens. In pharmaceutical research, benzothiazole derivatives, including 2-methylbenzo[d]thiazole-6-carboxylic acid, have been reported to exhibit a wide range of biological activities, including antifungal, antibacterial, antitubercular, antimalarial, anticonvulsant, anti-inflammatory, and anticancer properties, and have also been investigated as potential treatments for diabetes. In addition, 2-methylbenzo[d]thiazole-6-carboxylic acid can be used as a corrosion inhibitor and is an important raw material for the synthesis of various benzothiazole derivatives used in industrial applications, such as dyes and functional materials.

Product Parameters

Why Cosperpharm?

● GMP-certified facilities – ensuring high purity and batch-to-batch consistency

● Scalable production capacity – 150+ reactors (20L–5000L) supporting gram-to-kilogram production

● Global supply chain – serving 30+ partners worldwide

● Full documentation support – providing COA, stability data, MSDS for regulatory filings

● Competitive lead times – 1–2 months for bulk orders

● Responsive technical support – experienced R&D team available for analytical and synthesis consultation

Product Advantages

● Privileged benzothiazole scaffold – The benzothiazole core is a versatile framework in medicinal chemistry, conferring diverse biological activities and allowing for structure–activity relationship (SAR) optimization.

● Fungicidal research reagent – Recognized as a reagent for synthetic studies on fungicidal agents, making it a valuable tool for developing new agrochemicals to protect crops against plant‑pathogenic fungi, including seed‑ and soil‑borne pathogens.

● Broad‑spectrum biological potential – Derivatives of 2-methylbenzo[d]thiazole-6-carboxylic acid have been reported to exhibit antifungal, antibacterial, antitubercular, antimalarial, anticonvulsant, anti‑inflammatory, anticancer, and antidiabetic activities.

● Targeted protein engagement – Benzothiazole derivatives have shown binding affinity for the DprE1 enzyme in Mycobacterium tuberculosis, a validated target in antitubercular drug discovery, suggesting their potential in developing new tuberculosis therapeutics.

● Corrosion inhibition – Related benzothiazole-substituted carboxylic acids have been described as effective rust‑preventive agents for both iron and copper metals, highlighting their utility in industrial corrosion inhibition applications.

● High thermal stability – With a high melting point of 229–232 °C and an estimated flash point above 150 °C, the compound exhibits exceptional thermal stability, making it suitable for high‑temperature synthesis and formulation.

● High purity – Standard ≥95% ensures reliable results; higher purity grades available upon request

● Versatile chemical handle – The carboxylic acid group offers a variety of derivatization pathways, including amide coupling, esterification, and reduction, enabling the creation of diverse compound libraries

Storage Conditions

● Temperature: Sealed in  dry, 2–8°C (refrigerated) — do not freeze

● Container: Airtight, tightly sealed container

● Protection: Store away from moisture, light, and strong oxidizing agents

● Desiccation: Keep in a dry environment; the compound may be hygroscopic

● Stability: Stable under recommended storage conditions for up to 24 months

● Shelf life: 24 months when stored as recommended

● Incompatibilities: Strong oxidizing agents, strong bases, and strong acids

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