Adiphenine Hydrochloride is a pivotal anticholinergic API and research reagent used in the study of cholinergic receptors. As a non-competitive inhibitor of nicotinic acetylcholine receptors, Adiphenine Hydrochloride blocks the function of various nAChR subtypes, including α1, α3β4, α4β2, and α4β4 subunit-containing receptors . Additionally, Adiphenine Hydrochloride inhibits muscarinic acetylcholine receptors with a Ki of 0.44 µM . In research contexts, Adiphenine Hydrochloride is widely used as a pharmacological tool to investigate the role of cholinergic signaling in neuromuscular transmission, neuroprotection, and drug discovery. In quality control and pharmaceutical development contexts, Adiphenine Hydrochloride reference standards are essential for analytical method development, method validation, and regulatory submissions. With its broad-spectrum anticholinergic activity and established pharmacological profile, Adiphenine Hydrochloride remains a compound of continued interest in both medicinal chemistry and neuroscience research.
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Parameter |
Specification |
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Product Name |
Adiphenine Hydrochloride |
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CAS Number |
50-42-0 |
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Molecular Formula |
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Molecular Weight |
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Appearance |
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Melting Point |
168-171°C |
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Density |
1.0555 |
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Storage Condition |
-20°C (powder, 3 years) |
Adiphenine HCl is a nicotinic receptor inhibitor used as an antispasmodic drug.
Broad-Spectrum Anticholinergic Activity
Adiphenine Hydrochloride acts as a potent antagonist at both nicotinic and muscarinic acetylcholine receptors. It inhibits α1-nAChR (IC₅₀=1.9 µM), α3β4-nAChR (IC₅₀=1.8 µM), α4β2-nAChR (IC₅₀=3.7 µM), α4β4-nAChR (IC₅₀=6.3 µM), and muscarinic receptors (Ki=0.44 µM) .
Well-Characterized Pharmacological Tool
Adiphenine Hydrochloride is extensively characterized in the scientific literature, with established IC₅₀ and Ki values across multiple receptor subtypes, making it a reliable reference compound for cholinergic research .
Dual-Use: API and Research Reagent
Cosperpharm supplies Adiphenine Hydrochloride at multiple quality levels: high-purity API grade for pharmaceutical manufacturing, and research grade for nAChR and mAChR functional studies.
Established Therapeutic Use
Adiphenine Hydrochloride has been used clinically as an antispasmodic agent and has also been investigated as a potential protective agent against organophosphate-induced toxicity (PD50 = 3.3 mg/kg) .
Broad Research Applications
Beyond anticholinergic studies, Adiphenine Hydrochloride is used in research on neuroprotection, seizure models (ED50 = 62 mg/kg in MES model), and as a local anesthetic .
Q1: What is Adiphenine Hydrochloride used for?
A: Adiphenine Hydrochloride is an anticholinergic agent that acts as a non-competitive inhibitor of nicotinic acetylcholine receptors. It has been used as an antispasmodic drug and is widely used as a pharmacological tool in cholinergic research .
Q2: How does Adiphenine Hydrochloride work?
A: Adiphenine Hydrochloride blocks the function of nicotinic acetylcholine receptors (nAChRs) in a non-competitive manner, with IC₅₀ values of 1.9 µM (α1), 1.8 µM (α3β4), 3.7 µM (α4β2), and 6.3 µM (α4β4). It also inhibits muscarinic acetylcholine receptors with a Ki of 0.44 µM .
Partnering with Cosperpharm for your Adiphenine Hydrochloride requirements means securing a reliable supply chain for your cholinergic research program or pharmaceutical development. Contact us today to discuss your specifications.
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