Bazedoxifene is a pivotal pharmaceutical intermediate and certified reference standard in the industrial synthesis and quality control of this clinically approved SERM. The indole core of Bazedoxifene is typically constructed via Bischler indole synthesis between α-bromopropiophenone and 4-(benzyloxy)aniline hydrochloride, followed by deprotection and side-chain introduction. In quality control contexts, Bazedoxifene and its related impurities—including Bazedoxifene Impurity 1, Impurity 5, Impurity 8, and various degradation products—are essential analytical reference standards for impurity profiling, analytical method development, forced degradation studies, and quality control testing for generic manufacturers. As a third-generation SERM that also exhibits properties of a selective estrogen receptor degrader (SERD), Bazedoxifene demonstrates unique tissue-specific activity. The indole scaffold of Bazedoxifene serves as a versatile platform for estrogen receptor modulation, making this compound indispensable for pharmaceutical manufacturers developing generic versions and for analytical laboratories performing quality control testing.
Product Parameters
|
Parameter |
Specification |
|
Product Name |
Bazedoxifene |
|
CAS Number |
198481-32-2 |
|
Molecular Formula |
C₃₀H₃₄N₂O₃ |
|
Molecular Weight |
470.60 g/mol |
|
Melting Point |
98–102°C |
|
Boiling Point |
694.4±55.0 °C (Predicted) |
|
Density |
1.19 g/cm³ |
|
Storage Condition |
Sealed in dry, Store in freezer, under –20°C |
Bioactivity
Target
Why Cosperpharm?
Indole core integrity begins with the reference standard. The indole scaffold in Bazedoxifene is essential for estrogen receptor binding and tissue-selective activity. Any impurity in this material will compromise your analytical method accuracy and final product quality. Our analytical release protocol for Bazedoxifene includes HPLC purity verification (≥98%), water content determination, residual solvent analysis, and full identity confirmation—because your analytical results depend on the quality of this reference material.
Documentation that supports regulatory submission. Every reference-grade shipment includes a Certificate of Analysis (COA) with batch-specific HPLC purity, chromatographic traceability, and residual solvent data—structured for direct insertion into your method validation package. DMF-ready documentation, stability summaries, and custom quality agreements are available upon request.
Flexible supply across all development stages. Cosperpharm supplies Bazedoxifene across the full range of applications—from reference standard quantities for QC impurity profiling and analytical method development, to bulk quantities for generic API manufacturing. R&D samples ship within 5–7 business days; bulk orders ship within 2–3 weeks.
Technical support for impurity profiling. Our analytical chemistry team can advise on the selection of appropriate impurity reference standards, HPLC/UPLC method development for Bazedoxifene-related substances, and detection of process-related impurities—because we have extensive experience with this indole-based scaffold.
Global reach with transparent pricing. Cosperpharm ships to pharmaceutical manufacturers, CROs, and analytical laboratories worldwide, with full customs documentation included. Volume discounts apply at larger scales, and we communicate lead times upfront—no hidden fees, no unexpected delays.
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No. 2 Yangguang 3rd Road, Duodao Chemical Cycle Industrial Park, Jingmen City, Hubei Province, China
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