oxane-3,5-dione

oxane-3,5-dione is a versatile 1,3‑dicarbonyl synthon employed in the construction of fused and spiro‑heterocyclic compounds. When reacted with hydrazine hydrate, oxane-3,5-dione undergoes double condensation to directly yield 3,5‑bridged pyrazoles in which the tetrahydropyran oxygen provides an additional hydrogen‑bond acceptor. In drug discovery, oxane-3,5-dione is particularly valuable for generating libraries of pyrano‑fused heterocycles where the saturation of the pyran ring improves aqueous solubility and reduces aromatic interactions. Because oxane-3,5-dione can be prepared as a stable, isolable solid, it can be used as a reliable building block in both manual and automated parallel synthesis platforms without the formation of intractable enol‑ether by‑products.

Product Parameters

Quality Assurance at Cosperpharm

Each batch undergoes:

● Gas chromatography (GC) – purity ≥97.0%

● Non‑aqueous titration – purity ≥97.0%

● Refractive index – confirmatory analysis

● ¹H NMR – structural verification

● Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

Storage Conditions

Store oxane-3,5-dione in a tightly sealed container under an inert atmosphere of nitrogen or argon at 2–8 °C. Protect from moisture, as the dione is susceptible to hydrate formation. Under these conditions, the powder remains >97% pure for 12–18 months.

Appliation Scenarios

1.Fused Heterocycle Library Synthesis

Condensation with diverse bis‑nucleophiles generates pyrano‑pyrazoles, ‑isoxazoles, and ‑pyrimidines.

2.CNS‑Penetrant Scaffold Construction

The tetrahydropyran ring improves sp³ character and aqueous solubility, key parameters for brain exposure.

3.Anti‑Infective Core Exploration

Fused pyrano‑pyrazole analogs have been screened for antibacterial and antimycobacterial activity.

4.Fragment‑Based Drug Discovery

The compact, saturated, and oxygen‑rich nature makes it an attractive fragment hit for X‑ray soaking.

5.Process Development

Serves as a starting material for manufacturing ethyl pyrano[4,3‑c]pyrazole‑3‑carboxylate on multi‑kilogram scale.

Contact Us

Interested in exploring this unsaturated dione as a core scaffold for your next library? Reach out to Cosperpharm’s R&D chemicals desk — we can provide a small evaluation sample and discuss custom-scale production if the initial results are promising.