Papaverine Hydrochloride (CAS 61-25-6), chemically identified as 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline hydrochloride, is a benzylisoquinoline alkaloid originally found in opium.
Papaverine Hydrochloride is a chemical that functions as a smooth muscle relaxant, exerting its mode of action by inhibiting the enzyme phosphodiesterase and leading to an increase in intracellular levels of cyclic adenosine monophosphate (cAMP). This increase in cAMP levels results in the relaxation of smooth muscle cells, particularly those found in the blood vessels. By causing vasodilation, Papaverine Hydrochloride can increase blood flow to certain tissues and organs. Papaverine Hydrochloride′s mode of action also involves its ability to directly affect the contractility of smooth muscle cells, leading to a reduction in muscle tone and relaxation of the muscle fibers. In experimental applications, Papaverine Hydrochloride is used to study the effects of smooth muscle relaxation and vasodilation on various physiological processes.
Product Parameters
Parameter
Specification
Product Name
Papaverine Hydrochloride
CAS Number
61-25-6
EINECS Number
200-502-1
Molecular Formula
C₂₀H₂₂ClNO₄
Molecular Weight
375.85 g/mol
Appearance
White powder
Melting Point
226 °C (dec.)
pH
3.0–4.0 (20 g/L, 25 °C)
Storage Condition
Amber vial, refrigerated
FAQ
Q1: What is the mechanism of action of Papaverine Hydrochloride?
A: Papaverine Hydrochloride functions as a smooth muscle relaxant by inhibiting the enzyme phosphodiesterase, leading to increased intracellular cAMP levels and relaxation of smooth muscle cells, particularly in blood vessels.
Q2: How should this compound be stored?
A: Store Papaverine Hydrochloride in an amber vial under refrigeration. The compound is light sensitive and should be protected from light.
Storage Conditions
Store Papaverine Hydrochloride in an amber vial under refrigeration (2–8 °C) in a tightly sealed container. Protect from light as the compound is light sensitive. Keep the container dry and stored in a clean, well-ventilated area away from strong oxidizing agents.
Shelf life: Refer to the Certificate of Analysis for batch-specific expiry date.
Handling precautions: Use only in a fume hood. Wear chemical-resistant gloves, safety goggles, and a lab coat. Avoid generating dust or aerosols.
Application Scenarios
Smooth Muscle Relaxation Studies
Used to study the effects of smooth muscle relaxation and vasodilation on various physiological processes
Phosphodiesterase Inhibition Research
Serves as a tool compound for studying PDE inhibition and cAMP signaling pathways
Vasodilation Studies
Used to investigate cerebral vasodilation and vascular physiology
Calcium Channel Research
Studied for its calcium channel actions in vascular smooth muscle
Pharmaceutical Formulation Development
Used in the development of formulations for impotence treatment and other indications
Analytical Method Development
Serves as a reference standard for HPLC method development and quality control
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