Products

The product Fmoc-N-Methyl-L-Val-OH (IUPAC: N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valine, also known as Fmoc-N-Me-Val-OH) is a specialized N-α-Fmoc protected derivative of N-methyl-L-valine. The molecule is built upon the branched aliphatic side chain of valine, but the defining structural modification is the substitution of the backbone amide hydrogen with a methyl group at the nitrogen atom.

Fmoc-AzaTrp-OH (Fmoc-L-7-azatryptophan, also known as (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid) is a specialized Fmoc‑protected amino acid building block that incorporates an aza‑indole ring system in place of the standard indole side chain of tryptophan. The Fmoc protecting group at the N‑terminus enables seamless integration into standard Fmoc SPPS workflows, while the 7‑azatryptophan moiety introduces a nitrogen atom into the indole ring that significantly alters the electronic and hydrogen‑bonding properties of the side chain.

Boc-Pip(Fmoc)-OH (4-(Boc-amino)-1-Fmoc-piperidine-4-carboxylic acid, CAS 368866-07-3) is a conformationally constrained unnatural amino acid derivative built upon a piperidine ring system. The molecule features a piperidine-4-carboxylic acid core with two orthogonal protecting groups: a tert-butoxycarbonyl (Boc) group protecting the 4-amino nitrogen, and a 9-fluorenylmethoxycarbonyl (Fmoc) group protecting the ring nitrogen at the 1-position.

Fmoc-Sar-OH.H2O is the Fmoc‑protected form of sarcosine (N‑methylglycine), supplied as the monohydrate crystalline form. Sarcosine is the simplest N‑alkylated amino acid, featuring a secondary amino group (—NH—) in place of the primary amino group found in standard α‑amino acids. This structural difference fundamentally alters the conformational behavior of sarcosine‑containing peptides: the N‑methyl group restricts backbone flexibility, reduces the propensity for hydrogen‑bonding, and imparts unique secondary structure preferences not accessible with conventional amino acid residues.

Fmoc-N-Me-Trp(Boc)-OH (N-α-(9-Fluorenylmethoxycarbonyl)-N-α-methyl-N-in-tert-butoxycarbonyl-L-tryptophan, CAS 197632-75-0) is a di-protected N-methylated tryptophan derivative designed for Fmoc-based solid-phase peptide synthesis (SPPS). The molecule incorporates three key structural features: an Fmoc group protecting the α-amino function, an N-methyl group at the α-nitrogen, and a Boc group protecting the indole nitrogen of the tryptophan side chain.

Fmoc-Asp(OMpe)-OH (N-α-Fmoc-L-aspartic acid β‑3‑methylpent‑3‑yl ester) is an Fmoc‑protected L‑aspartic acid derivative bearing the sterically demanding β‑3‑methylpent‑3‑yl (OMpe) side‑chain protecting group. The compound was specifically developed as an advanced alternative to the standard Fmoc‑Asp(OtBu)‑OH for use in Fmoc solid‑phase peptide synthesis (SPPS), where repetitive piperidine treatment during Fmoc deprotection can otherwise trigger extensive aspartimide‑related by‑product formation at aspartyl residues, particularly in Asp‑Gly, Asp‑Ser, and Asp‑Thr sequences.