Trifarotene

Trifarotene is a pivotal pharmaceutical active ingredient and research compound in dermatology, functioning as a highly selective RARγ agonist for the treatment of congenital ichthyosis and acne vulgaris . As the first topical retinoid approved in nearly 25 years, Trifarotene offers a targeted approach to retinoid therapy by selectively engaging RARγ, the predominant retinoic acid receptor subtype in the epidermis . This selectivity profile means that Trifarotene can modulate keratinocyte differentiation, desquamation, and inflammation with reduced potential for the skin irritation and systemic side effects associated with pan-agonists and RARα/β-selective compounds . In clinical and research applications, Trifarotene has demonstrated dose-dependent comedolytic activity, being fully efficacious at 0.01% with a 98% reduction in comedones in preclinical models . The compound's unique terphenyl scaffold and favorable solubility characteristics—soluble in DMSO at 250 mg/mL (543.97 mM)—make Trifarotene an invaluable tool for both mechanistic studies of retinoid signaling and as a reference standard for analytical method development in pharmaceutical quality control .

Product Parameters

Why Cosperpharm?

When your dermatology research, method validation program, or pharmaceutical development requires reliable RARγ agonist reference material, Cosperpharm delivers Trifarotene with the analytical rigor, documentation depth, and supply flexibility that researchers demand.

Potency begins with purity. The biological activity of Trifarotene in RARγ binding and functional assays depends critically on compound integrity. Any degradation products or impurities could confound your receptor binding data and compromise your selectivity determinations. Our analytical release protocol for Trifarotene includes HPLC purity verification (≥98.0%), identity confirmation, and solubility testing—because the reliability of your pharmacology data depends on the quality of your test compound.

Documentation that supports your research and regulatory needs. As a reference standard for analytical method development and quality control applications, Trifarotene shipments include a comprehensive Certificate of Analysis (COA) with batch-specific HPLC purity, chromatographic traceability, and identity confirmation. Custom quality documentation, stability summaries, and analytical validation reports are available to support both publication and regulatory submission requirements.

Flexible supply across all research scales. Cosperpharm supplies Trifarotene across the full range of applications—from 5mg–100mg quantities for in vitro pharmacology and cell-based assays, to gram-scale batches for formulation studies and stability testing. R&D samples ship within 5–7 business days, with expedited options for urgent programs.

Technical expertise grounded in retinoid science. Our scientific team can provide guidance on Trifarotene solubility, formulation, and stability for various assay systems, as well as analytical methods for detecting related substances—because we understand the nuances of this selective RARγ agonist and its applications.

Global reach with transparent pricing. Cosperpharm ships to pharmaceutical companies, CROs, and academic institutions worldwide with full customs documentation. Volume discounts apply at larger scales, and we communicate lead times upfront.

 FAQ

Q1: What is the mechanism of action of Trifarotene?

A: Trifarotene is a potent and selective agonist of retinoic acid receptor gamma (RARγ), the predominant RAR subtype in the epidermis . By selectively activating RARγ, Trifarotene modulates genes involved in keratinocyte differentiation, desquamation, cornification, and cell adhesion, with an EC50 of 7.7 nM and ~65-fold selectivity over RARα .

Q2: What is the solubility of Trifarotene?

A: Trifarotene is soluble in DMSO at 250 mg/mL (543.97 mM) with ultrasonic assistance . Researchers are advised to perform solubility tests in their specific assay media.

Product Quality Assurance

Cosperpharm has established a comprehensive quality assurance system for Trifarotene that meets the rigorous expectations of both pharmaceutical research and reference standard applications:

Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: HPLC purity (≥98.0% with full chromatographic traceability), appearance verification, solubility confirmation, and identity verification. Physical property verification is conducted in accordance with established specifications.

Full batch traceability with retention samples. From raw material procurement through synthesis, purification, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with sufficient retention samples maintained in accordance with Cosperpharm quality procedures.

Stability monitoring program. Cosperpharm conducts ongoing stability studies under recommended storage conditions: long-term storage at –20°C under dry, dark conditions. Stability summaries are updated regularly, with full data packages available to support customer research and regulatory requirements. Shelf life: at least 12 months at –20°C .

Documentation ready for research and regulatory submission. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, a Material Safety Data Sheet (SDS), and customs documentation for international delivery. For customers preparing regulatory submissions or requiring comprehensive documentation, Cosperpharm provides custom quality agreements, stability data packages, and analytical validation reports upon request.

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm's manufacturing, quality control, and documentation facilities. Please contact our regulatory team to schedule an audit.

Contact Us

Your dermatology research deserves the confidence that comes with reliable compound quality—and Cosperpharm delivers precisely that. Reach out to us to discover how we can support your work with Trifarotene of uncompromising purity and traceability.