3',4'-Difluoroacetophenone

3',4'-Difluoroacetophenone is a high‑volume fluorinated intermediate used across the pharmaceutical and agrochemical industries. In the manufacture of triazole antifungals, 3',4'-Difluoroacetophenone serves as the precursor to the key chiral epoxide or alcohol that defines the voriconazole and posaconazole classes. The carbonyl group of 3',4'-Difluoroacetophenone is highly responsive to asymmetric reduction, enabling the production of enantiopure 1‑(3,4‑difluorophenyl)ethanol with >99% ee using tailored ketoreductases or chiral oxazaborolidine catalysts. Beyond antifungals, 3',4'-Difluoroacetophenone is employed to prepare fluorinated chalcones, α‑bromoketones, and imines that populate screening libraries for kinase inhibitors and GABA receptor modulators.

Product Parameters

Safety Information Summary

Synthetic Route

At room temperature, anhydrous aluminum trichloride (117 g) was slowly added to a mixture of 1,2-difluorobenzene (50 g) and acetyl chloride (86 g). The resulting slurry was heated to 30 °C under continuous stirring. Upon completion of the reaction, the red mixture was cooled to 20 °C and then slowly poured into a 800-g ice-water mixture while continuing stirring for 30 minutes. The organic phase was separated, and the aqueous phase was extracted with dichloromethane (3 × 50 mL). All organic phases were combined and washed successively with water (2 × 500 mL), saturated sodium bicarbonate solution (2 × 500 mL), and 15% saline solution (2 × 500 mL), followed by drying with anhydrous sodium sulfate. The organic phase was concentrated to remove solvents and finally distilled under reduced pressure; the fraction at 95 °C/13 mm Hg yielded 3 ',4' -difluorobenzylacetone (51 g).

Quality Assurance at Cosperpharm

Each batch undergoes:

● Gas chromatography (GC) – purity ≥97.0%

● Non‑aqueous titration – purity ≥97.0%

● Refractive index – confirmatory analysis

● ¹H NMR – structural verification

● Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

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