Fesoterodine

Fesoterodine is a pivotal active pharmaceutical ingredient (API) and certified reference standard in the treatment of overactive bladder syndrome. As a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties, Fesoterodine binds to and inhibits muscarinic receptors on the bladder detrusor muscle, preventing bladder contractions or spasms caused by acetylcholine. As a prodrug, Fesoterodine is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine, which is a muscarinic M2 and M3-receptor antagonist with antispasmodic activity. In quality control and pharmaceutical development contexts, Fesoterodine reference standards are essential for analytical method development, method validation, quality control testing, and regulatory submissions. The fumarate salt form of Fesoterodine—Fesoterodine Fumarate (CAS 286930-03-8)—ensures better solubility and stability for oral dosage forms, making it the preferred form for pharmaceutical manufacturing.

 

Product Parameters

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Parameter	Specification
Product Name	Fesoterodine
CAS Number	250214-44-9
Molecular Formula	C₃₀H₄₁NO₇
Molecular Weight	411.6 g/mol
Boiling Point	518.9±50.0 °C
Density	1.043 g/cm³
pKa	14.27±0.10 (Predicted)

Why Cosperpharm?

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When your overactive bladder therapeutic development or ANDA filing requires reliable API and reference standards, Cosperpharm delivers Fesoterodine with the analytical rigor, documentation depth, and supply flexibility that pharmaceutical customers demand.

 

Prodrug quality begins with the API. Fesoterodine is a prodrug that must undergo rapid and complete de-esterification to its active metabolite 5-HMT. Any impurity in this starting material can affect the prodrug conversion profile and compromise therapeutic efficacy. Our analytical release protocol includes HPLC purity verification, chiral purity analysis, residual solvent testing, and identity confirmation—because your final drug product quality depends on the integrity of this API.

 

Documentation that supports regulatory submission. Fesoterodine reference standards are essential for ANDA and NDA submissions. Every shipment includes a Certificate of Analysis (COA) with batch-specific HPLC purity, chromatographic traceability, and residual solvent data—structured for direct insertion into your method validation package. DMF-ready documentation, stability summaries, and custom quality agreements are available upon request.

 

Flexible supply across all development stages. Cosperpharm supplies Fesoterodine and Fesoterodine Fumarate across the full range of applications—from gram-scale reference standard quantities for QC impurity profiling and analytical method development, to bulk quantities for commercial manufacturing. R&D samples ship within 5–7 business days; bulk orders ship within 2–3 weeks.

 

Technical support for the full synthetic cascade. Our process chemistry team can advise on the selection of synthetic routes for the key intermediate (R)-2-[3-(Diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol, esterification conditions, and analytical methods for detecting process-related impurities—because we have worked extensively with this muscarinic antagonist across multiple manufacturing campaigns.

 

Global reach with transparent pricing. Cosperpharm ships to pharmaceutical manufacturers, CROs, and analytical laboratories worldwide, with full customs documentation included. Volume discounts apply at larger scales, and we communicate lead times upfront—no hidden fees, no unexpected delays.

 

Storage Conditions

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Store Fesoterodine and Fesoterodine Fumarate in a tightly sealed container, protected from light and moisture, under recommended storage conditions. Keep the container dry and stored in a clean, well-ventilated area away from strong oxidizing agents and sources of ignition. The compound is stable under recommended storage conditions.

 

Handling precautions: Use only in a fume hood. Wear chemical-resistant gloves, safety goggles, and a lab coat. Avoid generating dust or aerosols. Do not eat, drink or smoke in work areas. After handling, wash hands thoroughly. Refer to the Safety Data Sheet (SDS) for complete safety information.

FAQ

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Q1: What is Fesoterodine used for?

A: Fesoterodine is used for the treatment of overactive bladder (OAB), a condition characterized by urinary urgency, frequency, and incontinence. It is marketed under the brand name Toviaz®.

 

Q2: How does Fesoterodine work?

A: Fesoterodine is a competitive muscarinic receptor antagonist. It binds to and inhibits muscarinic receptors on the bladder detrusor muscle, preventing bladder contractions or spasms caused by acetylcholine. As a prodrug, it is rapidly de-esterified to its active metabolite 5-hydroxymethyl tolterodine.

 

Contact Us

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Partnering with Cosperpharm for your Fesoterodine requirements means securing a reliable supply chain for your overactive bladder therapeutic program. Reach out today to discuss your specifications.